首页|CD27在食管癌中的表达及其潜在基因通路的综合分析

CD27在食管癌中的表达及其潜在基因通路的综合分析

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目的 探讨CD27 在食管癌中表达差异及其潜在基因调控通路.方法 本研究运用基于基因表达水平值的交互式分析平台(GEPIA),cBio-Porta 分析CD27 在食管癌中的表达差异和突变的情况;运用 GEPIA做 Kaplan-Meier曲线分析CD27 在食管癌和头颈部鳞癌患者预后的价值;运用linkedomics做CD27 在食管癌中的功能和通路分析,并做Pearson 相关系数分析.结果 CD27 在食管癌中以扩增突变为主,不同水平的CD27 在食管癌中的表达对TOR复合体、多种激酶(KIT原癌基因受体酪氨酸激酶、转化生长因子受体 1、G蛋白偶联受体激酶 3)有潜在的影响;CD27 对头颈部鳞癌患者生存有显著影响,虽然对食管癌总生存没有显著影响,但高组的总生存较好.结论 CD27 的差异表达可能是食管癌发生发展的关键因素.本研究结果提示CD27 的表达程度有可能作为食管癌的生物标志物.
CD27 expression in esophageal carcinoma and its potential gene regulatory pathways
Objective To investigate the expression profile of CD27 in esophageal carcinoma and its potential gene regulatory pathways.Methods In this study,gene expression profiling interactive analysis(GEPIA)and cBio-Porta were used to analyze the differential expression and mutation of CD27 in esophageal cancer;GEPIA was used to perform Kaplan Meier curve analysis on the prognostic value of CD27 in patients with esophageal cancer and head and neck squamous cell carcinoma;functions and pathway enrichment of CD27 in esophageal cancer were performed by linkedomics through Pearson correlation coefficient analysis.Results The main type of CD27 mutation was amplification mutation in esophageal cancer.The expression of CD27 in esophageal carcinoma showed profound effects on TOR complex and various kinases(KIT-proto-oncogene receptor tyrosine kinase,transforming growth factor receptor 1,G protein-coupled receptor kinase 3).CD27 showed significant impact on overall survival of head and neck squamous cell carcinoma,and although it had no such effect on the overall survival of esophageal cancer,the patients with high expression had better overall survival.Conclusion The differential expression of CD27 may be a key factor in the occurrence and development of esophageal carcinoma.Our results suggest that the expression of CD27 might be a biomarker for esophageal cancer.

esophageal carcinomaCD27pathway enrichment

肖凡凱、王琳、杨帆

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郑州大学第一附属医院肿瘤科,郑州 450052

郑州大学第一附属医院互联网医疗系统与应用国家工程实验室,郑州 450052

郑州大学第一附属医院心血管内科,郑州 450052

食管癌 CD27 通路富集

河南省自然科学基金青年基金河南省医学科技攻关计划联合项目

202300410416LHGJ20190033

2024

中华老年多器官疾病杂志
中国人民解放军总医院老年心血管病研究所

中华老年多器官疾病杂志

CSTPCD
影响因子:0.728
ISSN:1671-5403
年,卷(期):2024.23(4)
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