Progress in research of lncRNA-mediated ceRNA networks in gouty arthritis
Long non-coding RNAs(lncRNAs)are non-coding RNAs(ncRNAs)greater than 200nt in length and have been found in recent years to act as sponges for microRNAs(miRNAs)and regulate competing endogenous RNA(ceRNA)networks.Studies have shown that lncRNAs are aberrantly expressed in gouty arthritis and are closely related to toll-like receptor/nod-like receptor(TLR/NLR)signaling pathway and purinergic ligand-gated ion channel 7 receptor(P2X7R)signaling pathway.LncRNAs can affect the occurrence and development of gout through multiple lncRNA-miRNA-mRNA axes.This article discusses the progress in the lncRNA-mediated ceRNA regulatory network in gout to deepen our understanding of the pathogenesis of gout in the view to providing new ideas for targeted inter-vention in gout inflammation and prevention of bone erosion.
long non-coding RNAcompeting endogenous RNAgout arthritis
NETL
NSTL
万方数据
维普
