Progress in research of ventilator-induced diaphragm dysfunction and weaning-induced pulmonary oedema
Diaphragm dysfunction and weaning-induced pulmonary oedema are two important causes of weaning failure.Diaphragm dysfunction can reduce contraction force of the diaphragm,compromising pulmonary ventilation loss and causing a subsequent weaning failure.Large negative swings in intrathoracic pressure during weaning tend to increase the venous return and the left ventricular after-load,contributing to weaning-induced pulmonary oedema and respiratory distress.This article reviews the mechanisms,diagnosis and strategies of treatment of diaphragm dysfunction and weaning-induced pulmonary oedema.