Research progress on correlation between mitochondrial DNA and coronary heart disease
Mitochondria,as body's energy factory,have their own separate genome—mitochondrial DNA(mtDNA).Normal energy supply of mitochondria is of great importance to myocardium,a high energy consuming tissue,while mtDNA can affect the energy supply of mitochondria to a certain extent.According to the latest Global Burden of Disease study,cardiovascular disease(CVD)is the top cause of death,and coronary heart disease(CHD)is one of the leading causes of death for CVD patients.As a newly discovered biomarker,mtDNA has a strong correlation with the pathogenesis,potential therapeutic targets and prognosis of CHD.In this article,we review the research progress of the correlation between mtDNA and CHD.
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