Influence of chemotherapy-induced liver injury on quality of life of elderly patients with breast cancer and its risk factors
Objective To determine the influence of chemotherapy-induced liver injury on quality of life in elderly patients with breast cancer,and to analyze the risk factors for liver injury.Methods A total of 226 elderly patients with breast cancer who underwent standard chemotherapy in our hospital from January 2021 to September 2022 were enrolled,and according to their liver injury evaluated with common terminology criteria for adverse events version 4.0(CTCAE4.0)of United States Department of Health and Human Services,they were divided into liver injury group(58 cases)and non-liver injury group(168 cases).Functional assessment of cancer therapy-breast(FACT-B)was applied to compare the quality of life between the two groups of patients.The one-year survival rate was also compared between them.SPSS statistics 24.0 was used for data analysis.Depending on data type,Chi-square test,student's t test or rank sum test was employed for intergroup comparison.Logistic regression analysis was applied to assess the influencing factors for chemotherapy-induced liver injury in elderly patients with breast cancer.Results The scores of physiological status,functional status and breast cancer-specific module and total score of FACT-B were significantly lower in the liver injury group than the non-liver injury group(P<0.05).Logistic regression analysis showed that intensive chemotherapy(OR=5.425,95％CI 3.227-9.120;P<0.05)and chemotherapy regimen of anthracy-clines+taxanes(OR=3.367,95％CI 1.881-6.028;P<0.05)were the risk factors for chemotherapy-induced liver injury in elderly patients with breast cancer.After one year of follow-up,14 cases of missing follow-up were eliminated,and the one-year survival rate was 86.79％(46/53)in the liver injury group and 94.97％(151/159)in the non-liver injury group,but there was no statistical difference between them(P>0.05).Conclusion Chemotherapy-induced liver injury cause a decrease in the quality of life of elderly breast cancer patients.Intensive chemotherapy and combined chemotherapy of anthracyclines and taxanes may increase the risk of liver injury.But further observation is needed to determine the effect of chemotherapy-induced liver injury on prognosis in future.
agedbreast cancerchemotherapyliver injuryquality of life
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