摘要
骨关节炎（OA）是一种慢性炎症性关节疾病，其病理改变主要为软骨退行性变。社会老龄化的加剧使得OA的发病率和致残率逐步攀升，成为困扰人类健康的社会问题之一。近年来，人们对代谢异常与OA相关性的研究兴趣增加，出现了诸多代谢异常与OA相关联的研究成果。肝脏是人体代谢的核心器官，国内外一系列研究表明大量OA患者肝酶学存在异常，在OA的发生、发展中起重要作用。本文着眼于肝酶代谢在OA发生、发展中的作用及机制，对相关文献作一综述。
Abstract
Osteoarthritis (OA) is a chronic inflammatory joint disease whose pathological changes are mainly degenerative changes of cartilage. The aggravation of social aging makes the incidence rate and disability rate of OA gradually rise, which has become one of the social problems puzzling human health. In recent years, there has been an increased interest in research on the correlation between metabolic abnormalities and OA, and many research results have emerged on the association between metabolic abnormalities and OA. The liver is the core organ of human metabolism, and a series of studies at home and abroad have shown that a large number of patients with OA have abnormal liver enzymology, which plays an important role in the occurrence and development of OA. In this paper, we focus on the role and mechanism of liver enzyme metabolism in the occurrence and development of OA and review the relevant literature.
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