Effects of hyperbaric oxygen on Osteocalcin and VEGF expression after lateral sinus lifting augmentation with xenograft:a preliminary in-vivo investigation on histomorphometric analysis
Effects of hyperbaric oxygen on Osteocalcin and VEGF expression after lateral sinus lifting augmentation with xenograft:a preliminary in-vivo investigation on histomorphometric analysis
Objective To analyze the promotion of osteogenic factors secretion utilizing hyperbaric oxygen(HBO)on sinus floor elevation(SFE)patients.Methods A total of 5 patients that need lateral SFE for implants were enrolled in this study.Pure Xenografts(Bio-Oss,Geistlich,Switzerland)were used for all the patients.After lateral SFE surgery,3 patients as the test groups received 100％HBO therapy for 5 weeks(T1),6 weeks(T2),and 9 weeks(T3),respectively.The other 2 patients healed naturally for 6 weeks(ctrl)and 13 months(TM)as the control groups.Biopsies were harvested and Quantitative histomorphometric analysis were performed regarding two key factors(BPG and VEGF)in different groups.Data was analyzed with ANOVA and Tukey pairwise comparison.Results Significant greater expression for both factors was found on test groups compared to control groups(P＜0.001).No significance within the control groups was found for both factors.Within test groups,the lowest level of BPG appeared on T2,while T1 and T3 showed no difference(P=0.0900).For VEGF,the peak appeared on T1,no difference with T2 and T3 was found(P=0.0739).Both BPG and VEGF showed quadratic trends,presenting an initial upward trend and eventually a downward trend depending on T1,T2 and T3 groups.Conclusions HBO therapy at early healing stage after lateral SFE with pure Xenograft significantly improved the secretion of VEGF and BPG.Keeping HBO until 5th to 6th week after surgery may maximized its efficiency on early bone healing stage.
维普
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