Objective To investigate the value of peripheral blood neutrophil to lymphocyte ratio(preoperative neutrophil-to-lymphocyte ratio,NLR)combined with depth of tumor invasion(depth of invasion,DOI)in predicting cervical lymph node metastasis in patients with early tongue squamous cell carcinoma(tongue squamous cell carcinoma,TSCC).Methods A clinical retrospective study was conducted on 96 patients with cT1/2N0 stage TSCC who visited the hospital from January 1,2017 to December 1,2023.Based on pathological results,they were divided into a neck lymphnode positive group(pN+,n=34)and a negative group(pN-,n=62).Peripheral blood neutrophil and lymphocyte counts,DOI,and other data were collected from the patients.The factors influencing cervical lymph node metastasis were analyzed by univariate and multifactorial analysis.Receiver Operating Characteristic Curve was used to analyze the ability of NLR,DOI,and their combination to predict early cervical lymph node metastasis in TSCC patients.Results The NLR,DOI,nerve and vascular invasion in the pN+group were significantly higher than those in the pN-group(P＜0.05),and the degree of tumor differentiation was significantly lower than that in the pN-group(P＜0.05).NLR and DOI were independent risk factors for cervical lymph node metastasis in early TSCC patients(P＜0.05).The optimal cutoff value for predicting occult lymph node metastasis in the neck using NLR was 2.18,with an area under the curve of 0.70,sensitivity of 70.6%,and specificity of 61.3%.The optimal cutoff value for predicting occult lymph node metastasis in the neck using DOI was 5.55mm,with an area under the curve of 0.88,sensitivity of 86.3%,and specificity of 71.4%.Combining the two indicators,the optimal cutoff area under the curve for predictingcervical lymph node metastasis is 0.91,sensitivity of 88.2%,and specificity of 82.3%.Conclusion NLR and DOI have certain value in predicting cervical lymph node metastasis in early TSCC patients,and their combined predictive value is better than a single indicator,which canprovide reference for clinical diagnosis and treatment strategies.
关键词
舌鳞状细胞癌/中性粒细胞与淋巴细胞比值/浸润深度/颈淋巴结转移
Key words
Tongue squamous cell carcinoma/Neutrophil to lymphocyte ratio/Depth of invasion/Cervical lymph node metastasis
维普
万方数据