As a high-risk group for cancer,a considerable number of elderly patients require the removal of intraoral fixed restorations due to radiation therapy requirements.Metal and zirconia,as two mainstream fixed prosthesis,are widely used in clinical practice.At present,there is a consensus on the impact of oral metal-based restorative materials on radiographic imaging,but their impact on radiotherapy have not been comprehensively reported.In order to balance the necessity of systemic treatment and the guarantee of oral function in clinical practice,the retention of fixed restorations is no longer a"one-size-fits-all"approach,but needs to be discussed on a case by case basis.This article starts with the principles of radiation therapy and summarizes the effects of two commonly used dental materials-metal-based materials and zirconia on radiotherapy,in order to provide some reference for future clinical treatment.