Clinically,oral soft and hard tissue defects caused by oral inflammation,maxillofacial trauma,tumors and congenital diseases are very common,which affect oral function and appearance. Concentrated growth factors (CGF) was first proposed by Sacco in 2006. CGF is a third-generation concentrated platelet extracted from autologous venous blood,isolated and prepared by special variable speed centrifugation. Compared with platelet-rich plasma and platelet-rich fibrin,CGF irich in higher concentrations of growth factors and a more ductile fibrin grid. A large number of basic studies have shown that growth factors can promote cell proliferation. Because CGF is convenient to obtain materials,simple to prepare,and has no risk of immune rejection,it is widely used in oral implant,periodontal,maxillofacial surgery and other fields,in addition,its application in the dental pulp,facial repair and other fields is also gradually increasing. Therefore,CGF is more and more recognized by clinicians. The current application scope and postoperative effect of CGF in stomatology were reviewed in order to provide some theoretical basis for clinical and follow-up studies.
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