摘要
阿尔茨海默病是老年期常见的以进行性认知功能下降、精神行为异常和多种功能受损为主要表现的认知障碍性疾病,阻塞性睡眠呼吸暂停是常见的呼吸障碍类型,研究发现两者在发病风险、生物标志物及神经影像等多方面存在关联,并可能通过神经病理蛋白沉积、免疫炎症加重、氧化应激异常、线粒体功能受损及神经递质系统紊乱等多种机制建立关联.本文对阿尔茨海默病与阻塞性睡眠呼吸暂停的关系、机制及治疗进行论述.
Abstract
Alzheimer's disease(AD)is the most common cognitive disorder in the elderly and manifests primarily as progressive cognitive function decline,neuropsychiatric symptoms and multiple functional impairments.Obstructive sleep apnea(OSA)is a common type of respiratory disorder.Studies have found that AD and OSA are connected in many ways,including the risk of developing these diseases,biomarkers and neuroimaging features.These connections may result from a variety of mechanisms,such as neuropathological protein deposition,exacerbated immune-mediated inflammation,oxidative stress abnormalities,impaired mitochondrial function,and disturbed neurotransmitter systems,among others.This article reviewed the relationship between AD and OSA,the mechanisms linking them and their treatment.
基金项目
国家重点研发计划-欧盟地平线2020计划合作项目(2017YFE0118800-779238)
国家重点研发计划重大慢性非传染性疾病防控研究重点专项(2016YFC1306300)
国家重点研发计划重大慢性非传染性疾病防控研究重点专项(2016YFC1306000)
国家自然科学基金面上项目(81970992)
国家自然科学基金面上项目(81571229)
首都卫生发展科研专项(首发)(2022-2-2048)
NETL
NSTL
维普
万方数据