摘要
轻度认知功能障碍(MCI)是痴呆的前驱形式,其在病因、临床表现、进展结局以及预后上存在异质性,有关MCI的分型研究逐年增加.本文从表型特征、病因、进展结局、数据驱动等视角分别探讨MCI的亚型划分并梳理各分型的流行病学特征、影响因素以及其进展为痴呆的风险.虽然MCI分型研究日益增多,但不同视角下MCI亚型间的相关性研究仍非常有限,亟待进一步探讨,以期更为精准有效地开展MCI的诊断与治疗,为痴呆的预防提供参考.
Abstract
Mild cognitive impairment(MCI)is a prodromal phase of dementia with heterogeneity in etiology,clinical presentation,disease progression,outcome,and prognosis.The number of studies on MCI subtypes is increasing each year.This article discussed the subtypes of MCI from the perspectives of phenotypic characteristics,etiology,progression,outcome,and data-driven approaches,and further summarizes the epidemiological characteristics,influencing factors,and risk of progression to dementia of each subtype.Despite the increasing number of studies on MCI subtyping,research remains limited on the correlation between MCI subtypes from different perspectives,indicating a need for further investigation in order to achieve more accurate and effective diagnosis and treatment of MCI and obtain evidence for dementia prevention.
NETL
NSTL
维普
万方数据