The correlation between serum Klotho levels and frailty in elderly people
Objective To examine the correlation between serum Klotho levels and frailty in elderly people.Methods In this cross-sectional study,150 community-dwelling elderly people aged 65 years and over were enrolled.Subjects were divided into a frail(n=50,33.3％),a pre-frail(n=47,31.3％)and a non-frail(n=53,35.3％)group based on the Fried phenotype.General participant data,routine laboratory test results,short physical performance battery(SPPB)results and human body composition data were collected.Serum Klotho protein levels were measured by an enzyme-linked immunosorbent assay.The relationship between serum Klotho protein levels and frailty was analyzed by using Spearmen's correlation analysis and Logistic regression analysis.Results Klotho protein levels were lower in the frail group than in the non-frail group(P=0.001),whereas differences between the frail group and the pre-frail group and between the pre-frail group and the non-frail group were not statistically significant(all P＞0.05).When Klotho protein levels were classified into four quartiles,i.e.,Q1,Q2,Q3,and Q4,using three cut-off vales(2.28,3.52,and 5.09 mg/L),the prevalences of frailty were 51.4％(19/37),39.5％(15/38),24.3％(9/37)and 18.4％(7/38),respectively.The prevalence of frailty decreased with increasing Klotho protein levels(X2=11.204,P=0.011).Spearman correlation analysis showed that the Klotho protein level was negatively correlated with frailty(r=-0.310,P＜0.001).Multivariate Logistic regression analysis results showed that age(OR=1.109,95％CI:1.011-1.217,P=0.028)and sarcopenia(OR=6.511,95％CI:1.279-33.147,P=0.024)were risk factors for frailty,while walking(OR=0.104,95％CI:0.033-0.326,P＜0.001),a high SPPB score(OR=0.780,95％CI:0.627-0.970,P=0.026),and a high Klotho protein level(OR=0.752,95％CI:0.581-0.974,P=0.031)were protective factors against frailty.Conclusions The serum Klotho protein level may be used as a parameter for the assessment of frailty.It is negatively correlated with frailty,suggesting that elderly people with low serum Klotho protein levels are at high risk of developing frailty.
万方数据
维普
