Serum CX3CL1 levels and their clinical significance in Alzheimer's disease patients
Objective To examine the relationship between serum CX3CL1 levels and clinical features of Alzheimer's disease(AD)patients.Methods 44 AD patients admitted to affiliated Hangzhou Xixi hospital between September 2018 and June 2022 were assigned into the AD group,32 patients with mild cognitive impairment(MCI)entered the MCI group and 33 healthy people served as the control group.A turbidimetric immunoassay was used to measure serum CX3CL1 levels of the groups.Cognitive function was evaluated by the mini-mental state examination(MMSE).Magnetic resonance imaging(MRI)was used to measure brain atrophy.The correlation of the CX3CL1 level with the course of disease,disease severity and the degree of brain atrophy in AD patients was analyzed.Results AD Patients had lower serum CX3CL1 levels compared with the control group[(0.45±0.10)ng/ml vs.(0.51±0.07)ng/ml,P=0.01]and the MCI group[(0.45±0.10)ng/ml vs.(0.57±0.08)ng/ml,P＜0.001].Serum CX3CL1 levels in the MCI group were significantly higher than those in the control group[(0.57±0.08)ng/ml vs.(0.51±0.07)ng/ml,P=0.03].Serum CX3CL1 levels were significantly lower in AD patients with MMSE≤10 than those with MMSE＞10[(0.40±0.07)ng/ml vs.(0.47±0.11)ng/ml,t=-2.57,P＜0.05].AD patients with brain atrophy had lower CX3CL1 levels than those without brain atrophy[(0.41±0.09)ng/ml vs.(0.51±0.08)ng/ml,t=-3.79,P＜0.05].Correlation analysis showed that there was a positive correlations between the serum CX3CL1 level and the MMSE score(r=0.417,P＜0.05).The disease duration,the linear measures of the brain volume including the Huckman number,the third ventricular index and the suprasellar cistern area ratio were negatively correlated with serum CX3CL1 levels(r--0.638,-0.335,-0.562,-0.393,respectively,all P＜0.05).However,serum CX3CL1 levels had no clear correlation with disease duration,MMSE score and linear measures of the brain volume in MCI patients(r=-0.120,-0.065,0.129,-0.061,0.035,respectively,all P＞0.05).The area under the ROC-plot for CX3CL1 was 0.83(95％CI:0.73-0.92).The optimal cut-off value for CX3CL1 was 0.48 ng/ml with a sensitivity of 66％and a specificity of 91％.Conclusions AD patients have low serum CX3CL1 levels,which are associated with disease severity and brain atrophy.Measurement of serum CX3CL1 in MCI patients has some predictive value for AD.
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