The predictive value of the CARG tool for treatment-related toxicity in elderly cancer patients:a meta-analysis
Objective To systematically review the predictive value of the Cancer Aging Research Group(CARG)tool for treatment-related toxicity in older patients with cancer.Methods The online CNKI,Wanfang,VIP,PubMed and Web of Science databases were searched,including publications from the earliest electronic records to May 2022,to identify all relevant articles assessing the predictive value of CARG in older patients with cancer.QUADAS-2 was used for literature quality evaluation,and RevMan 5.4.1 and Meta-DiSc 1.4 were used for meta-analysis.Results A total of 17 articles were included in the study,including 2 284 elderly cancer patients,aged 65-94 years.Among them,1 261 patients experienced grade 3-5 toxicity.With a CARG score less than 6 considered as low risk,the combined sensitivity,specificity and AUC for predicting chemotherapy toxicity were 0.79(0.76-0.81),0.39(0.36-0.42)and 0.693(standard error 0.050),respectively;With a score less than 10 considered as low risk,the combined sensitivity,specificity and AUC for predicting chemotherapy toxicity were 0.30(0.27-0.32),0.75(0.72-0.78)and 0.361(standard error:0.050).Conclusions The predictive value of the CARG tool for treatment-related toxicity in elderly cancer patients is of moderate importance,and more research is needed to improve our understanding of how to appropriately use CARG for assessment.
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