生长停滞特异性蛋白6/TAM信号在阿尔茨海默病中的研究进展
Research progress of Gas6/TAM signaling in Alzheimer's disease
刘婷 1刘承云1
作者信息
- 1. 华中科技大学同济医学院附属协和医院老年医学科,武汉 430022
- 折叠
摘要
生长停滞特异性蛋白6(Gas6)是一种维生素K依赖性蛋白,通过与TAM(包括Tyro3、Ax1和MerTK 3种跨膜酪氨酸激酶受体)结合发挥作用.人们已经对该系统做出了许多研究,该系统在调节免疫反应、炎症、凝血、细胞生长和凋亡体清除方面发挥作用.研究发现,Gas6/TAM受体在神经炎症、神经胶质细胞吞噬功能中扮演重要角色.本文主要回顾Gas6/TAM系统的生物学功能以及其在阿尔茨海默病(AD)发病机制中的潜在作用及药物治疗前景.
Abstract
Growth arrest specificity protein 6(Gas6)is a vitamin K-dependent protein that interacts with three transmembrane tyrosine kinase receptors:Tyro3,Ax1,and MerTK,collectively known as TAM.This pleiotropic system has been extensively studied in recent decades,leading to a better understanding of its role in regulating immune responses,inflammation,blood coagulation,cell growth,and apoptotic body clearance.Recent studies have revealed the significance of Gas6 and TAM receptors in neuroinflammation and glial cell phagocytosis.This review primarily focuses on the biological functions of the Gas6/TAM system and its potential contribution to the development of Alzheimer's disease(AD),as well as the possibilities of drug treatment.
关键词
阿尔茨海默病/中枢神经系统/生长停滞特异性蛋白6/TAM信号Key words
Alzheimer disease/Central nervous system/Growth arrest specificity protein 6/TAM signal引用本文复制引用
出版年
2024
NETL
NSTL
万方数据