Research progress of Gas6/TAM signaling in Alzheimer's disease
Growth arrest specificity protein 6(Gas6)is a vitamin K-dependent protein that interacts with three transmembrane tyrosine kinase receptors:Tyro3,Ax1,and MerTK,collectively known as TAM.This pleiotropic system has been extensively studied in recent decades,leading to a better understanding of its role in regulating immune responses,inflammation,blood coagulation,cell growth,and apoptotic body clearance.Recent studies have revealed the significance of Gas6 and TAM receptors in neuroinflammation and glial cell phagocytosis.This review primarily focuses on the biological functions of the Gas6/TAM system and its potential contribution to the development of Alzheimer's disease(AD),as well as the possibilities of drug treatment.
Alzheimer diseaseCentral nervous systemGrowth arrest specificity protein 6TAM signal
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