多系统萎缩患者疲乏的患病率及其与抑郁的关系
Prevalence of fatigue in patients with multiple system atrophy and its relationship with depression
潘竞 1康佳 1王新 1海日罕 1韩晓雨 1陈彪2
作者信息
- 1. 内蒙古医科大学第二附属医院内科中心,呼和浩特 010020
- 2. 首都医科大学宣武医院,北京市老年病医疗研究中心,神经生物室/神经内科/老年医学,北京 100053;首都医科大学脑重大疾病研究中心,北京脑重大疾病研究院,脑重大疾病防治省部共建协同创新中心,北京 100053;国家老年疾病临床医学研究中心,北京 100053
- 折叠
摘要
目的 探讨多系统萎缩(MSA)患者疲乏的患病率及其与焦虑抑郁的关系.方法 本研究为横断面研究,收集首都医科大学宣武医院的MSA住院患者44例,将疲乏严重程度量表(FSS)≥4分定义为存在疲乏,使用统一帕金森病评估量表(MDS-UPDRS)和统一多系统萎缩评估量表(UMSARS)对患者进行运动症状的评估,使用汉密尔顿抑郁量表(HAMD)、老年抑郁量表(GDS)和汉密尔顿焦虑量表(HAMA)评估患者焦虑抑郁情况.结果 患者年龄为(60.1±6.4)岁,FSS的得分为(4.3±2.4)分,其中,有28例(63.6％)患者存在疲乏.与非疲乏组患者相比,疲乏组患者存在明显的焦虑(HAMA分别为[(16.5±8.9)分和(9.4±5.0)分,t=-2.292,P=0.010]和抑郁(HAMD 分别为[(14.4±7.0)分和(8.4±3.4)分,t=6.192,P=0.017]与 GDS 分别为[(18.2±7.4)分和(10.7±5.2)分,t=-3.560,P=0.044].MSA患者的疲乏严重程度与焦虑(HAMA,r=0.516,P＜0.001)、抑郁(HAMD,r=0.551,P＜0.001)以及 GDS(r=0.636,P＜0.001)和日常生活能力得分(r=0.320,P=0.034)呈正相关,与患者的运动症状和疾病的严重程度无关.结论 近三分之二的MSA患者存在疲乏症状,疲乏与焦虑和抑郁水平显著相关,影响患者的情绪和日常生活.
Abstract
Objective Fatigue is one of the common disabling non-motor symptoms of multiple system atrophy(MSA).This study aimed to investigate the prevalence of fatigue in MSA patients and its relationship with anxiety and depression.Methods In this cross-sectional study,44 MSA inpatients from Xuanwu Hospital of Capital Medical University were enrolled.Fatigue was defined as a Fatigue Severity Scale(FSS)score ≥4.The motor symptoms of the patients were evaluated using the Unified Parkinson's Disease Rating Scale(MDS-UPDRS)and Unified Multi-System Atrophy Rating Scale(UMSARS).The Hamilton Rating Scale for Depression(HAMD),Geriatric Depression Scale(GDS)and Hamilton Anxiety Scale(HAMA)were used to assess anxiety and depression.Results The mean age of the MSA patients was 60.1±6.4 years,and the score of FSS was 4.3±2.4,with 28 patients(63.6％)having fatigue.Compared with the non-fatigue group,the fatigue group showed clear anxiety(HAMA:16.5±8.9 vs.9.4±5.0,t=-2.292,P=0.010)and depression(HAMD:14.4±7.0 vs.8.4±3.4,t=6.192,P=0.017;GDS:18.2±7.4 vs.10.7±5.2,t=-3.560,P=0.044).The severity of fatigue in MSA patients was positively correlated with anxiety(r=0.516,P＜0.001),depression(HAMD:r=0.551,P＜0.001;GDS:r=0.636,P=0.000)and the score of activities of daily living(r=0.320,P=0.034),but not correlated with motor symptoms or disease severity.Conclusions Nearly two-thirds of MSA patients have symptoms of fatigue,and fatigue is significantly associated with levels of anxiety and depression,affecting patients'mood and activities of daily living.
关键词
多系统萎缩/疲乏/焦虑/抑郁Key words
Multiple system atrophy/Fatigue/Anxiety/Depression引用本文复制引用
基金项目
国家重点研发计划(2021YFC2501200)
国家重点研发计划(2018YFC1312001)
内蒙古自治区自然科学基金(2020MS08138)
内蒙古自治区医疗卫生科技计划(202202216)
内蒙古医科大学项目(YKD2022LH024)
出版年
2024
NETL
NSTL
万方数据