Effects of vitamin D supplementation combined with dietary adjustment on blood glucose level and bone mineral density in elderly male patients with diabetes combined with osteosarcopenia
Objective To investigate the therapeutic impact of combining vitamin D supplementation with dietary adjustments on elderly male patients with diabetes and osteosarcopenia.Methods From January 2021 to May 2023,a total of 108 male patients diagnosed with diabetes and osteosarcopenia were admitted to Beijing hospital for research purposes.The patients were randomly assigned to either a control group(n=54)or a trial group(n=54).The control group received conventional dietary adjustments,while the trial group received vitamin D supplementation in addition to dietary adjustments.Various parameters including 25-(OH)-VitD3 levels,blood glucose levels,appendicular skeletal muscle mass index(ASMI),bone mineral density,and bone metabolism indexes were measured before and after the treatment in both groups.Results Compared to the pre-treatment period,the levels of 25-(OH)-VitD3,grip strength,6 m step speed,and ASMI increased in both groups,while fasting blood glucose and 2 h postprandial blood glucose decreased significantly(all P＜0.05).Additionally,the experimental group showed higher levels of 25-(OH)-VitD3,grip strength,6 m step speed,and ASMI compared to the control group post-treatment,with lower levels of fasting blood glucose and 2 h postprandial blood glucose(all P＜0.05).Compared with the pre-treatment period(bone density values in the lumbar spine:0.41±0.09,the hip:0.42±0.12 in the control group;bone density values in the lumbar spine:0.43±0.07,the hip:0.44±0.09 in the experimental group),the bone density values of the lumbar spine and the hip were higher in both groups after treatment(bone density values in the lumbar spine:0.76±0.12,the hip:0.78±0.12 in the control group;bone density values in the lumbar spine:0.95±0.22,the hip:0.97±0.28 in the experimental group).The bone density values of the lumbar spine and the hip in the experimental group were higher than those of the control group after treatment(all P＜0.05).Furthermore,serum concentrations of parathyroid hormone(PTH)and osteoclast differentiation factor(RANKL)were significantly lower,while serum osteocalcin(OCN)was significantly higher in both groups post-treatment(all P＜0.05).In the experimental group,serum PTH and RANKL concentrations were significantly lower and serum OCN was significantly higher compared to the control group post-treatment(all P＜0.05).Conclusions The results show that incorporating vitamin D into dietary changes can effectively regulate blood glucose levels,decrease bone loss,enhance bone density,and improve muscle quality in this patient population.
Vitamin DDiabetes mellitusSarcopeniaOsteoporosisBone density
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