The role of dopamine in Parkinson's disease-related pain and research progress
Pain is one of the most important non-motor symptoms of Parkinson's disease(PD)and seriously affects life quality.Mechanisms underlying how the central nervous system processes PD-related pain involve both the dopaminergic and non-dopaminergic systems.In recent years,numerous studies have demonstrated the involvement of dopamine in the perception,conduction,and regulation of both acute and chronic pain.Dopamine is believed to be a crucial neurotransmitter in the regulation of pain sensation.In order to elucidate the role of dopamine in PD-associated pain,this paper systematically addressed this issue from several perspectives,including structures and dopaminergic neural circuits implicated in PD-related pain,and cellular and molecular mechanisms.Additionally,potential avenues for future research on PD-related pain are outlined.
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