Analysis of related factors of frailty in very elderly patients with multimorbidity
Objective To investigate the factors contributing to frailty in very elderly patients with multimorbidity.Methods This cross-sectional study enrolled 119 very elderly patients with multimorbidity who were hospitalized in the Department of Geriatrics of Huadong Hospital Affiliated to Fudan University from August 2022 to March 2023.The study aimed to understand the basic status of multimorbidity by collecting general information,the number and types of diseases,and frailty status.The subjects were divided into frail and non-frail groups through comprehensive geriatric assessment.Various factors including gender,age,Tinetti balance gait score,risk of sarcopenia,dementia,depression,risk of deep vein thrombosis,dysphagia,comorbidity index,medication count,Basic Activities of Daily Living(BADL)score,Instrumental Activities of Daily Living(IADL)score,Nutritional Risk Screening 2002(NRS-2002)score,Norton pressure injury risk assessment score,and Social Support Rating Scale(SSRS)score were compared.The correlation between each factor and the occurrence of frailty was analyzed using univariate analysis and multivariate Logistic regression analysis.Results A total of 119 elderly inpatients with multimorbidity,with an average age of 90.8±5.9 years old,were included in the study.The incidence of frailty was 68.9％(82 cases).Univariate analysis revealed significant statistical differences between the frail group and the non-frail group in various factors including age(t=-3.131,P=0.002),Tinetti score(Z=-5.544,P＜0.001),risk of sarcopenia(x2=39.205,P＜0.001),dysphagia(x2=5.937,P=0.015),Charlson comorbidity index(Z=-2.565,P=0.010),medication count(Z=-3.325,P＜0.001),BADL(Z=-5.871,P＜0.001),IADL(Z=-5.062,P＜0.001),Norton score(Z=-5.922,P＜0.001),and SSRS social support(Z=-2.637,P=0.008).Multivariate logistic regression analysis showed that the Tinetti score(OR=0.843,95％CI:0.737-0.966,P=0.014),decreased muscle strength(OR=11.226,95％CI:2.157-58.432,P=0.004),sarcopenia(OR=18.084,95％CI:2.041-106.211,P=0.009),Norton score(OR=0.462,95％CI:0.254-0.838,P=0.011),and medication count(OR=1.153,95％CI:1.000-1.329,P=0.049)were independently associated with frailty.Conclusions In very elderly patients with multimorbidities,the occurrence of frailty is notably increased.Frailty is linked to multiple risks including falls,muscle weakness/sarcopenia,pressure ulcer risk,and polypharmacy,and these risks are independent of other factors.
NETL
NSTL
万方数据
