Progress in clinical research on frontotemporal dementia related to mutations in the microtubule-associated protein tau gene
Frontotemporal dementia(FTD)is the second most common early-onset dementia after Alzheimer's disease.About 30％to 50％of FTD cases are related to genetic factors.Mutations in the microtubule-associated protein tau(MAPT)gene are common autosomal dominant gene mutations and are the third most common cause of inherited frontotemporal dementia.In this paper,we will review the structure,encoded protein,pathogenesis and pathologic features of the MAPT gene and the clinical phenotype,imaging features and treatment of FTD caused by MAPT gene mutations.
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