The mediating effect of depression in the associations between sleep quality and cognitive functions in elderly with mild cognitive impairment
Objective To examine the impact of sleep quality on cognitive function in older adults with mild cognitive impairment(MCI)and explore the potential mediating role of depression.Methods Using a cross-sectional design,we conducted an on-site questionnaire survey among 310 elderly individuals with MCI in Haishu District,Ningbo City from April to June 2021.Out of the 310 questionnaires collected,299 were deemed valid.The survey encompassed gathering basic demographic information of the participants,as well as administering the Montreal Cognitive Assessment Scale,Patient Health Questionnaire Depression Scale,and Pittsburgh Sleep Quality Index Scale.Results The cognitive functions of patients with MCI were found to be positively related to their education level(F=3.89,P＜0.05).The correlation analysis indicated that sleep quality was positively correlated with depression(r=0.40,P＜0.01)and negatively correlated with cognitive function(r=-0.22,P＜0.01).Furthermore,a significant negative correlation was observed between depression and cognitive function(r=-0.20,P＜0.01).The mediation analysis revealed that depression played a role in mediating the influence of sleep quality on cognitive function,with a mediation effect of-0.02(95％CI:-0.03--0.01).Conclusions The cognitive function of elderly individuals with MCI can be significantly affected by sleep quality,with depression playing a mediating role.
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