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前驱期多系统萎缩的研究进展

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多系统萎缩(MSA)是一种进展迅速的神经系统退行性疾病,和帕金森病(PD)、路易体痴呆(DLB)同属于α-突触核蛋白病.由于同类疾病早期临床症状的重叠以及目前诊断标准对疾病早期缺乏敏感性,开展疾病早期修饰治疗药物的临床试验困难重重,疾病修饰治疗药物的研发以及诊断工具的开发和验证进展缓慢.因此,国际运动障碍协会(MDS)开发了新的MSA诊断标准,首次提出可能的前驱期MSA的定义和诊断标准.本综述介绍了可能的前驱期MSA诊断标准以及与其他前驱期α-突触核蛋白病鉴别诊断,以提高疾病在早期阶段诊断的准确性,有利于疾病早期研究的开展.
Research progress on prodromal multiple system atrophy
Multiple system atrophy(MSA)is a rapidly progressive neurodegenerative disease and,along with Parkinson's disease(PD)and dementia with Lewy bodies(DLB),belongs to the group of α-synucleinopathies.Due to an overlap of clinical symptoms of similar diseases in the early stages and a lack of sensitivity of the current diagnostic criteria to detect the disease in the early stages,difficulties abound in conducting clinical trials on disease-modifying therapeutic agents for its early treatment,and progress in the development of disease-modifying therapeutic agents as well as the development and validation of diagnostic tools has been slow.Consequently,the International Movement Disorder Society(MDS)has introduced new diagnostic criteria for MSA,which,for the first time,propose a category known as possible prodromal MSA and its diagnostic criteria.This review described the diagnostic criteria for possible prodromal MSA and its differential diagnosis from other prodromal α-synucleinopathies,in order to improve the accuracy of diagnosis in the early stages and to promote research on the early stages of the disease.

Multiple system atrophyalpha-synucleinDifferential diagnosis

潘竞、康佳、王新、海日罕、陈彪

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内蒙古医科大学第二附属医院神经内科,呼和浩特 010010

首都医科大学宣武医院神经生物室/神经内科/老年医学,北京 100053

多系统萎缩 α突触核蛋白 诊断,鉴别

国家重点研发计划国家重点研发计划国家重点研发计划国家重点研发计划内蒙古自然科学基金内蒙古自治区医疗卫生科技计划项目内蒙古医科大学项目内蒙古医科大学项目

2021YFC25012002018YFC13120012017YFC08401052017YFC13102002020MS08138202202216YKD2022LH024YKD2023XK008

2024

10.3760/cma.j.issn.0254-9026.2024.09.016

中华老年医学杂志
中华医学会

中华老年医学杂志

CSTPCD北大核心
影响因子：1.606
ISSN：0254-9026
年,卷(期)：2024.43(9)