Multiple system atrophy(MSA)is a rapidly progressive neurodegenerative disease and,along with Parkinson's disease(PD)and dementia with Lewy bodies(DLB),belongs to the group of α-synucleinopathies.Due to an overlap of clinical symptoms of similar diseases in the early stages and a lack of sensitivity of the current diagnostic criteria to detect the disease in the early stages,difficulties abound in conducting clinical trials on disease-modifying therapeutic agents for its early treatment,and progress in the development of disease-modifying therapeutic agents as well as the development and validation of diagnostic tools has been slow.Consequently,the International Movement Disorder Society(MDS)has introduced new diagnostic criteria for MSA,which,for the first time,propose a category known as possible prodromal MSA and its diagnostic criteria.This review described the diagnostic criteria for possible prodromal MSA and its differential diagnosis from other prodromal α-synucleinopathies,in order to improve the accuracy of diagnosis in the early stages and to promote research on the early stages of the disease.
关键词
多系统萎缩/α突触核蛋白/诊断,鉴别
Key words
Multiple system atrophy/alpha-synuclein/Differential diagnosis
维普
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