摘要
阿尔茨海默病(AD)是最常见的认知障碍性疾病,其临床症状包括进行性认知功能下降、精神行为症状和多种功能受损.研究发现,AD患者常伴发复杂的视觉障碍,其甚至可以出现在认知功能受损之前.本文对AD患者视觉障碍的临床症状、视觉系统的变化、视觉障碍的发生机制、视觉系统生物标志物及治疗进展进行综述,有助于我们了解视觉系统改变及视觉障碍作为AD早期筛查、识别和干预的窗口所具有的潜能和价值,为AD的早诊早治提供依据.
Abstract
Alzheimer's disease(AD)is the most common cognitive disorder characterized by progressive cognitive decline,neuropsychiatric symptoms,and impaired multiple functions.Numerous studies have indicated that AD patients often experience complex visual impairment,which may even occur before cognitive impairment.In this review,we introduce the research progress on the clinical symptoms of visual impairment,changes in the visual system,mechanisms underlying visual impairment,ocular biomarkers,and therapeutic interventions in AD patients.This comprehensive review aims to enhance our understanding of visual system alterations and highlight the potential significance of visual impairment as an early screening tool for identifying and intervening in AD.Ultimately,this knowledge can serve as a foundation for the early diagnosis and treatment of AD.
基金项目
首都卫生发展科研专项(首发)(2022-2-2048)
北京市重大疑难疾病阿尔茨海默病中西医协同攻关项目(2023BJSZDYNJBXTGG-018)
国家重点研发计划(2016YFC1306300)
国家重点研发计划(2016YFC1306000)
国家自然科学基金面上项目(81970992)
维普
万方数据