Sarcopenia is a progressive disease characterized by the loss of skeletal muscle mass and function.The risk of developing sarcopenia increases with age,making it a significant clinical concern for the elderly.However,the molecular mechanism underlying this disease remains unclear,and there is a lack of consensus regarding treatment strategies and evaluation of their effectiveness.In recent years,researchers have explored various factors such as nutrition,exercise,and genetics to understand the mechanisms involved.One such regulatory pathway,the PI3K-Akt signaling pathway,has been found to be associated with multiple factors.This review aims to shed light on the regulatory mechanisms of cytokines,hormones,pro-inflammatory factors,and mitochondria within this pathway in the context of sarcopenia.By doing so,it hopes to offer new insights for the treatment of sarcopenia.
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