Research progress on the role of nicotinamide mononucleotide(NMN)in anti-aging and treatment of aging-associated diseases
Nicotinamide adenine dinucleotide(NAD+),a coenzyme for redox reactions crucial to energy metabolism,is also a required co-substrate for non-redox NAD+-dependent enzymes.NAD+participates in a wide range of biological functions within cells,including energy metabolism,DNA repair,cellular senescence,and epigenetics.It is also closely correlated with aging and aging-associated disorders.Recent research has indicated that supplementation with nicotinamide mononucleotide(NMN),a precursor of NAD+,can increase NAD+levels and has excellent preventive and therapeutic potential in a variety of age-related diseases,such as cardiovascular diseases,neurodegenerative diseases,renal diseases,endocrine and metabolic diseases,reproductive system diseases and malignant tumors.This paper provided a comprehensive review of recent research advances on NAD+metabolism and the role of NMN in anti-aging and aging-associated diseases.
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