Association and predictive value of blood lipids and carotid atherosclerosis in the elderly
Objective To investigate the association and predictive value of serum biomarkers with carotid atherosclerosis(CAS)in the elderly population.Methods The data used in this study were obtained from the China Hainan Centenarian Cohort Study(CHCCS),a prospective cohort that includes elderly individuals from community populations in Hainan Province.The baseline survey was conducted between 2014 and 2019.A total of 737 elderly individuals aged 80 to 100 were included in the analysis.The study examined various factors including questionnaires,physical examination data,liver and kidney function indicators(albumin,aspartate aminotransferase,alanine aminotransferase,total bilirubin,and glomerular filtration rate),blood cell counts(red blood cells,white blood cells,platelets,neutrophil count,lymphocyte count,and monocyte count),inflammatory markers(high-sensitivity C-reactive protein),and lipid metabolism markers(total cholesterol,triglycerides,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,apolipoprotein AI,and apolipoprotein B).The objective was to explore the lipids of serum biomarkers and diagnostic performance of carotid atherosclerosis.Results The prevalence of CAS in the elderly population was found to be 80.7％.Spearman's correlation analysis and a fully adjusted multivariate logistic regression model were used to examine the relationship between CAS and various factors in elderly patients.Result showed that systolic blood pressure,heart rate,and serum apolipoprotein B levels were significantly correlated with CAS[OR(95％CI):1.012(1.004-1.021),0.998(1.011-1.024);15.796(4.914-50.772),respectively;all P＜0.001].Additionally,ROC curve analysis demonstrated that the combined application of serum apolipoprotein B,systolic blood pressure,and heart rate improved the predictive value of CAS in the elderly(Area under the curve:0.820,95％CI:0.782-0.858;Sensitivity:78.8％;Specificity:86.8％;Positive likelihood ratio:5.97;Negative likelihood ratio:0.24).Conclusions Our study discovered that serum apolipoprotein B is an autonomous risk factor for CAS among the elderly.The utilization of a specific set of biomarkers,in conjunction with other risk markers,holds potential as a promising strategy for evaluating CAS in the elderly population.
Advanced ageLipid metabolismCarotid atherosclerosisApolipoprotein B
万方数据
维普
