Alzheimer's disease(AD)represents a significant public health challenge globally.Achieving precise diagnosis in the early stages of AD is a critical issue that requires resolution.In accordance with the revised criteria for the diagnosis and staging of AD established by the Alzheimer's Association(A A)Workgroup,we have summarized the latest biomarker categorizations,biological staging,and numeric clinical staging of AD.Additionally,we discuss the implications of these findings for clinical practice,which will offer compelling approaches for the precise diagnosis and understanding of mechanisms involved in early AD.