The relationship between serum calcium levels and pain in patients with Parkinson's disease
Objective To investigate the relationship between serum calcium levels and pain in patients with Parkinson's disease(PD).Methods A total of 111 patients with PD and 50 healthy volunteers were recruited from our hospital between July 2019 and June 2020.Motor symptoms of PD patients were assessed using the Hoehn-Yahr(H&Y)stages and the Unified Parkinson's Disease Rating Scale-Ⅲ(UPDRS Ⅲ).Non-motor symptoms were evaluated using Mini-Mental State Examination(MMSE),17-item Hamilton Depression Rating Scale(HAMD-17),14-item Hamilton Anxiety Rating Scale(HAMA-14),questionnaire for rapid eye movement(REM)sleep behavior disorder(RBDQ-HK),King Parkinson's pain scale(KPPS),Pittsburgh Sleep Quality Index(PSQI),Parkinson's Disease Sleep Scale(PDSS),and Epworth Sleepiness Scale(ESS).The quality of life of PD patients was assessed using the 39-item Parkinson's Disease Questionnaire(PDQ-39).Results The levels of serum calcium in PD patients were significantly lower than those in the control group(t=3.733,P＜0.001).Additionally,the levels of serum calcium in PD patients with pain were higher than those in PD patients without pain(t=-3.238,P＜0.05).This suggests a significant positive correlation between serum calcium levels and pain in PD patients(r=0.320,P=0.001).When analyzing serum calcium levels for PD with pain using binary logistic regression,the area under the curve(AUC=0.662)and sensitivity(28.9％)were found to be low.Furthermore,a correlation analysis of KPPS scores in PD patients with pain revealed that KPPS scores were correlated with UPDRSⅢ(r=0.383,P=0.009),HAMD-17(r=0.303,P=0.043),HAMA-14(r=0.303,P=0.043),PSQI(r=0.304,P=0.042),and PDSS(r=-0.417,P=0.004)scores.Conclusions The levels of serum calcium are decreased in patients with Parkinson's disease(PD),and there is a correlation between serum calcium levels and pain experienced by PD patients.However,it is important to note that pain in PD patients is influenced by various other factors.
万方数据
维普
