摘要
目的 探讨血清钙水平与帕金森病(PD)患者疼痛的相关性.方法 连续收集自2019年7月至2020年6月在我院住院的PD患者111例及50例健康志愿者.采用Hoehn-Yahr(H&Y)分级和统一帕金森病评定量表第三部分(UPDRSⅢ)评定PD的运动症状;采用简易精神状态检查(MMSE)、汉密尔顿抑郁量表-17项(HAMD-17)、汉密尔顿焦虑量表-14项(HAMA-14)、快动眼睡眠行为障碍问卷(RBDQ-HK)、King帕金森病疼痛量表(KPPS)、匹兹堡睡眠质量指数(PSQI)、帕金森病睡眠量表(PDSS)、爱泼沃斯嗜睡量表(ESS)分别评估患者的非运动症状;采用39项PD调查表(PDQ-39)评估患者的生活质量.结果 PD患者血清钙水平低于对照组(t=3.733,P＜0.001),PD伴疼痛患者血清钙水平高于PD不伴疼痛患者(t=-3.238,P＜0.05);相关分析显示,血清钙水平与PD伴疼痛呈正相关(r=0.320,P=0.001);基于血清钙水平对PD伴疼痛的二元logistic回归分析显示曲线下面积(AUC=0.662)及敏感度(28.9％)较低,进而对PD伴疼痛患者的KPPS评分进行相关性分析得出 KPPS 评分与 UPDRSⅢ(r=0.383,P=0.009)、HAMD-17(r=0.303,P=0.043)、HAMA-14(r=0.303,P=0.043)、PSQI(r=0.304,P=0.042)、PDSS(r=-0.417,P=0.004)评分均相关.结论 PD患者血清钙水平降低,PD患者血清钙水平与疼痛相关,但PD患者疼痛仍受其他较多因素的影响.
Abstract
Objective To investigate the relationship between serum calcium levels and pain in patients with Parkinson's disease(PD).Methods A total of 111 patients with PD and 50 healthy volunteers were recruited from our hospital between July 2019 and June 2020.Motor symptoms of PD patients were assessed using the Hoehn-Yahr(H&Y)stages and the Unified Parkinson's Disease Rating Scale-Ⅲ(UPDRS Ⅲ).Non-motor symptoms were evaluated using Mini-Mental State Examination(MMSE),17-item Hamilton Depression Rating Scale(HAMD-17),14-item Hamilton Anxiety Rating Scale(HAMA-14),questionnaire for rapid eye movement(REM)sleep behavior disorder(RBDQ-HK),King Parkinson's pain scale(KPPS),Pittsburgh Sleep Quality Index(PSQI),Parkinson's Disease Sleep Scale(PDSS),and Epworth Sleepiness Scale(ESS).The quality of life of PD patients was assessed using the 39-item Parkinson's Disease Questionnaire(PDQ-39).Results The levels of serum calcium in PD patients were significantly lower than those in the control group(t=3.733,P＜0.001).Additionally,the levels of serum calcium in PD patients with pain were higher than those in PD patients without pain(t=-3.238,P＜0.05).This suggests a significant positive correlation between serum calcium levels and pain in PD patients(r=0.320,P=0.001).When analyzing serum calcium levels for PD with pain using binary logistic regression,the area under the curve(AUC=0.662)and sensitivity(28.9％)were found to be low.Furthermore,a correlation analysis of KPPS scores in PD patients with pain revealed that KPPS scores were correlated with UPDRSⅢ(r=0.383,P=0.009),HAMD-17(r=0.303,P=0.043),HAMA-14(r=0.303,P=0.043),PSQI(r=0.304,P=0.042),and PDSS(r=-0.417,P=0.004)scores.Conclusions The levels of serum calcium are decreased in patients with Parkinson's disease(PD),and there is a correlation between serum calcium levels and pain experienced by PD patients.However,it is important to note that pain in PD patients is influenced by various other factors.
维普
万方数据