目的 了解天津市新报告HIV感染者抗病毒治疗前病毒载量（VL）基线特征及相关因素。 方法 资料来源于中国疾病预防控制信息系统，研究对象为天津市2019-2022年新报告且首次抗病毒治疗前HIV感染者，收集其社会人口学特征、CD4+T淋巴细胞（CD4）计数及VL值等基线信息，基线高VL值定义标准为≥100 000拷贝数/ml，分析影响VL水平的相关因素。采用SPSS 24.0软件进行统计学分析。 结果 研究对象新报告HIV感染者共1 296例，其中，基线高VL值的HIV感染者占15.89%（206/1 296）。多因素logistic回归分析结果显示，有STD史者（aOR=1.45，95%CI：1.00~2.08），基线高VL值的可能性较大；相比于基线CD4计数<200个/µl者，基线CD4计数分别为200~350个/μl（aOR=0.40，95%CI：0.27~0.57）、351~500个/μl（aOR=0.32，95%CI：0.20~0.49）和>500个/µl者（aOR=0.30，95%CI：0.18~0.49）的基线高VL值的可能性较小。 结论 2019-2022年天津市HIV感染者抗病毒治疗前基线VL值高的比例较低，HIV感染者基线VL值高的相关因素为有STD史和基线CD4计数<200个/µl，艾滋病防控工作应给予重点关注。 Objective To understand the baseline viral load (VL) of newly reported HIV- infected patients before antiretroviral therapy and related factors in Tianjin. Methods Data were obtained from the China Disease Control and Prevention Information System, and the study subjects were HIV-infected patients before the first antiretroviral therapy in Tianjin from 2019 to 2022, and the information about their socio-demographic characteristics, baseline CD4+T lymphocyte (CD4) counts before antiretroviral therapy and baseline VL test results were collected, the baseline high VL was defined as ≥100 000 copies/ml. The effect of different factors on viral load were analyzed. Software SPSS 24.0 was used for statistical analysis. Results A total of 1 296 newly reported HIV-infected patients were included in the study, in whom 15.89% (206/1 296) had high baseline VL, and multifactorial logistic regression analysis showed that those with history of STD (aOR=1.45, 95%CI:1.00-2.08) were more likely to have high baseline VL. Compared with those with baseline CD4 counts <200 cells/μl, those with baseline CD4 counts 200-350 cells/μl (a OR=0.40, 95%CI: 0.27-0.57), 351-500 cells/μl (aOR=0.32, 95%CI: 0.20-0.49), and >500 cells/μl (a OR=0.30, 95%CI: 0.18-0.49) were less likely to have high baseline VL. Conclusions The proportion of HIV-infected patients with high baseline VL before antiretroviral therapy was low in Tianjin during 2019-2022. History of STD and baseline CD4 counts <200 cells/μl were associated with high baseline VL in HIV-infected patients, to which close attention needs to be paid in AIDS prevention and control.
Abstract
Objective To understand the baseline viral load (VL) of newly reported HIV- infected patients before antiretroviral therapy and related factors in Tianjin. Methods Data were obtained from the China Disease Control and Prevention Information System, and the study subjects were HIV-infected patients before the first antiretroviral therapy in Tianjin from 2019 to 2022, and the information about their socio-demographic characteristics, baseline CD4+T lymphocyte (CD4) counts before antiretroviral therapy and baseline VL test results were collected, the baseline high VL was defined as ≥100 000 copies/ml. The effect of different factors on viral load were analyzed. Software SPSS 24.0 was used for statistical analysis. Results A total of 1 296 newly reported HIV-infected patients were included in the study, in whom 15.89% (206/1 296) had high baseline VL, and multifactorial logistic regression analysis showed that those with history of STD (aOR=1.45, 95%CI:1.00-2.08) were more likely to have high baseline VL. Compared with those with baseline CD4 counts <200 cells/μl, those with baseline CD4 counts 200-350 cells/μl (a OR=0.40, 95%CI: 0.27-0.57), 351-500 cells/μl (aOR=0.32, 95%CI: 0.20-0.49), and >500 cells/μl (a OR=0.30, 95%CI: 0.18-0.49) were less likely to have high baseline VL. Conclusions The proportion of HIV-infected patients with high baseline VL before antiretroviral therapy was low in Tianjin during 2019-2022. History of STD and baseline CD4 counts <200 cells/μl were associated with high baseline VL in HIV-infected patients, to which close attention needs to be paid in AIDS prevention and control.
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