Association between vitamin D level and grip strength in adults aged 50 and older in Shanghai
董俣君 1郭雁飞 2阮晔 1孙双圆 1蒋安丽 1汪嘉琦 1施燕 1吴凡 3张婧
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作者信息
1. 上海市疾病预防控制中心慢性非传染病与伤害防治所，上海 200336
2. 上海市预防医学研究院，上海 200336
3. 复旦大学上海医学院，上海 200032
折叠
摘要
目的 探讨上海市≥50岁人群维生素D水平与握力的关系。 方法 数据来源于WHO全球老龄化与成人健康研究我国上海市2018-2019年数据，采用logistic回归模型分析维生素D水平与握力的关系，进一步按照性别、年龄及乳制品摄入情况进行分层；采用限制性立方样条曲线绘制维生素D水平与低握力的剂量-反应曲线。 结果 共4 391人纳入研究，其中男性2 054人（46.8%）；年龄（67.02±8.81）岁；低握力1 421人（32.4%）；维生素D不足及缺乏分别为1 533人（34.9%）和401人（9.1%）。在调整相关混杂因素后，logistic回归分析结果显示，维生素D缺乏的人群发生低握力的风险更高（OR=1.41，95%CI：1.09~1.83）；在男性中，调整相关混杂因素后，维生素D缺乏与低握力发生风险呈显著正相关（OR=1.67，95%CI：1.12~2.50），而女性中两者之间无关联（OR=1.30，95%CI：0.97~1.74）；在60~69岁及≥80岁年龄组中，调整相关混杂因素后，维生素D缺乏与低握力发生风险呈显著正相关（OR=1.57，95%CI：1.05~2.35；OR=2.40，95%CI：1.08~5.31），在乳制品摄入<250 ml/d的人群中，调整相关混杂因素后，二者之间呈显著正相关（OR=1.57，95%CI：1.17~2.09），而在乳制品摄入≥250 ml/d的人群中无明显关联。限制性立方条样图显示，低握力的发生风险可能随维生素D含量的上升而降低，但差异无统计学意义（P>0.05）。 结论 维生素D水平与握力存在一定的关系，维生素D缺乏人群出现低握力的风险更高。 Objective To understand the association between vitamin D level and grip strength in people aged ≥50 years in Shanghai. Methods Data were obtained from the WHO's Study on Global Ageing and Adult Health in Shanghai during 2018-2019. Logistic regression model was used to analyze the association between vitamin D level and grip strength, and a stratified analysis was conducted for different gender, age and dairy product intake groups. Restricted cubic spline was used to evaluate the dose-response association between vitamin D level and low grip strength. Results A total of 4 391 participants were included in the study, including 2 054 men (46.8%), with an average age of (67.02±8.81) years. And 1 421 individuals (32.4%) had low grip strength 1 533 individuals (34.9%) had vitamin D deficiency, and 401 individuals (9.1%) had vitamin D deficiency. After adjusted for confounding factors, the logistic regression results analysis showed that individuals with vitamin D deficiency had a higher risk for low grip strength (OR=1.41, 95%CI: 1.09-1.83). In men, after adjusting for confounding factors, vitamin D deficiency was positively associated with the risk for low grip strength (OR=1.67, 95%CI: 1.12-2.50), but there was no significant association between vitamin D level and grip strength in women (OR=1.30, 95%CI: 0.97-1.74). In age group 60-69 years and ≥80 years, there was significant association between vitamin D deficiency and low grip strength after adjusting for confounding factors (OR=1.57, 95%CI: 1.05-2.35 OR=2.40, 95%CI: 1.08-5.31). In people who had daily intake of dairy product <250 ml, there was positive association between vitamin D deficiency and low grip strength, but there was no significant association in people who had daily dairy product ≥250 ml after adjusting for confounding factors. The restrictive cubic spline demonstrated that risk of low grip strength might decreased with the increase of vitamin D levels, however, the difference was not significant ( P>0.05). Conclusions This study demonstrated that there is association between vitamin D level and grip strength. People with vitamin D deficiency have higher risk for low grip strength.
Abstract
Objective To understand the association between vitamin D level and grip strength in people aged ≥50 years in Shanghai. Methods Data were obtained from the WHO's Study on Global Ageing and Adult Health in Shanghai during 2018-2019. Logistic regression model was used to analyze the association between vitamin D level and grip strength, and a stratified analysis was conducted for different gender, age and dairy product intake groups. Restricted cubic spline was used to evaluate the dose-response association between vitamin D level and low grip strength. Results A total of 4 391 participants were included in the study, including 2 054 men (46.8%), with an average age of (67.02±8.81) years. And 1 421 individuals (32.4%) had low grip strength 1 533 individuals (34.9%) had vitamin D deficiency, and 401 individuals (9.1%) had vitamin D deficiency. After adjusted for confounding factors, the logistic regression results analysis showed that individuals with vitamin D deficiency had a higher risk for low grip strength (OR=1.41, 95%CI: 1.09-1.83). In men, after adjusting for confounding factors, vitamin D deficiency was positively associated with the risk for low grip strength (OR=1.67, 95%CI: 1.12-2.50), but there was no significant association between vitamin D level and grip strength in women (OR=1.30, 95%CI: 0.97-1.74). In age group 60-69 years and ≥80 years, there was significant association between vitamin D deficiency and low grip strength after adjusting for confounding factors (OR=1.57, 95%CI: 1.05-2.35 OR=2.40, 95%CI: 1.08-5.31). In people who had daily intake of dairy product <250 ml, there was positive association between vitamin D deficiency and low grip strength, but there was no significant association in people who had daily dairy product ≥250 ml after adjusting for confounding factors. The restrictive cubic spline demonstrated that risk of low grip strength might decreased with the increase of vitamin D levels, however, the difference was not significant ( P>0.05). Conclusions This study demonstrated that there is association between vitamin D level and grip strength. People with vitamin D deficiency have higher risk for low grip strength.
关键词
维生素D/握力/中老年人
Key words
Vitamin D/Grip strength/Middle-aged and elderly people
万方数据