目的 探讨职业人群饮酒行为与高血压及SBP、DBP的关联，分析体质指数（BMI）和血脂水平的中介作用，为职业人群的高血压预防提供参考。 方法 基于西南地区职业人群队列，通过问卷调查、体格和血生化检查收集人口学特征、行为生活方式、血压和血脂等情况。采用logistic回归分析和线性回归分析饮酒行为与高血压及SBP、DBP的关联，采用因果中介分析估计BMI、HDL-C、LDL-C、TG和TC的独立和联合中介效应，并结合网络分析探索饮酒行为、BMI、血脂水平与高血压之间的相互关联。 结果 共纳入22 887名研究对象，其中新发高血压1 825名。Logistic回归分析发现，与从不饮酒人群相比，现在饮/既往饮酒可使高血压风险增加33%（OR=1.33，95%CI：1.19~1.48）；饮酒行为可使SBP（β=1.05，95%CI：0.69~1.40）和DBP（β=1.10，95%CI：0.83~1.38）增加。联合中介分析发现，BMI和血脂介导了饮酒行为与高血压及SBP、DBP间21.91%、28.40%和22.64%的效应，其中BMI和TG为主要的中介因素，也是饮酒行为、BMI、血脂水平和血压网络中边权和桥强度中心性最高的2个中介节点。 结论 饮酒行为与患高血压风险升高有关，BMI和TG是重要的中介因素和网络中关键节点，提示应重点关注饮酒行为、BMI和TG，有助于职业人群的高血压预防。 Objective To investigate the association between alcohol consumption and hypertension and SBP, DBP and the mediating effects of body mass index (BMI) and lipid level in occupational population, and provide reference for the intervention and prevention of hypertension. Methods Based on the data of Southwest Occupational Population Cohort from China Railway Chengdu Group Co., Ltd., the information about the demographic characteristics, behavior and lifestyle, blood pressure and lipids level of the participants were collected through questionnaire survey, physical examination and blood biochemical test. Logistic/linear regression was used to analyze the association between alcohol consumption and hypertension, SBP and DBP. The individual and joint mediating effects of BMI, HDL-C, LDL-C, TG, and TC were explored through causal mediating analysis. A network analysis was used to explore the correlation between alcohol consumption, BMI and lipid levels, and hypertension. Results A total of 22 887 participants were included, in whom 1 825 had newly detected hypertension. Logistic regression analysis found that current/former drinkers had a 33% increase of risk for hypertension compared with never-drinkers (OR=1.33, 95%CI:1.19-1.48). Similarly, alcohol consumption could increase SBP (β=1.05, 95%CI:0.69-1.40) and DBP (β=1.10, 95%CI:0.83-1.38). Overall, BMI and lipid levels could mediate the associations between alcohol consumption and hypertension, SBP and DBP by 21.91%, 28.40% and 22.64%, respectively. BMI and TG were the main mediators, and they were also the two nodes with the highest edge weight and bridge strength centrality in the network of alcohol consumption, BMI, lipid levels and hypertension. Conclusions Alcohol consumption was associated with increased risk for hypertension, and BMI and TG were important mediators and key nodes in the network. It is suggested that paying attention to the alcohol consumption, BMI and TG might help prevent hypertension in occupational population.
Abstract
Objective To investigate the association between alcohol consumption and hypertension and SBP, DBP and the mediating effects of body mass index (BMI) and lipid level in occupational population, and provide reference for the intervention and prevention of hypertension. Methods Based on the data of Southwest Occupational Population Cohort from China Railway Chengdu Group Co., Ltd., the information about the demographic characteristics, behavior and lifestyle, blood pressure and lipids level of the participants were collected through questionnaire survey, physical examination and blood biochemical test. Logistic/linear regression was used to analyze the association between alcohol consumption and hypertension, SBP and DBP. The individual and joint mediating effects of BMI, HDL-C, LDL-C, TG, and TC were explored through causal mediating analysis. A network analysis was used to explore the correlation between alcohol consumption, BMI and lipid levels, and hypertension. Results A total of 22 887 participants were included, in whom 1 825 had newly detected hypertension. Logistic regression analysis found that current/former drinkers had a 33% increase of risk for hypertension compared with never-drinkers (OR=1.33, 95%CI:1.19-1.48). Similarly, alcohol consumption could increase SBP (β=1.05, 95%CI:0.69-1.40) and DBP (β=1.10, 95%CI:0.83-1.38). Overall, BMI and lipid levels could mediate the associations between alcohol consumption and hypertension, SBP and DBP by 21.91%, 28.40% and 22.64%, respectively. BMI and TG were the main mediators, and they were also the two nodes with the highest edge weight and bridge strength centrality in the network of alcohol consumption, BMI, lipid levels and hypertension. Conclusions Alcohol consumption was associated with increased risk for hypertension, and BMI and TG were important mediators and key nodes in the network. It is suggested that paying attention to the alcohol consumption, BMI and TG might help prevent hypertension in occupational population.
关键词
饮酒行为/高血压/体质指数/血脂/中介分析/网络分析
Key words
Alcohol consumption/Hypertension/Body mass index/Blood lipid/Mediation analysis/Network analysis
万方数据