Distribution and influencing factors of lipoprotein(a)levels in non-arteriosclerotic cardiovascular disease population in China
Objective To describe the distribution of lipoprotein(a)[Lp(a)]levels in non-arteriosclerotic cardiovascular disease(ASCVD)population in China and explore its influencing factors.Methods This study was based on a nested case-control study in the CKB study measured plasma biomarkers.Lp(a)levels was measured using a polyclonal antibody-based turbidimetric assay certified by the reference laboratory and ≥75.0 nmol/L defined as high Lp(a).Multiple logistic regression model was used to examine the factors related to Lp(a)levels.Results Among the 5 870 non-ASCVD population included in the analysis,Lp(a)levels showed a right-skewed distribution,with a M(Q1,Q3)of 17.5(8.8,43.5)nmol/L.The multiple logistic regression analysis found that female was associated with high Lp(a)(OR=1.23,95％CI:1.05-1.43).The risk of increased Lp(a)levels in subjects with abdominal obesity was significantly reduced(OR=0.68,95％CI:0.52-0.89).As TC,LDL-C,apolipoprotein A1(Apo A1),and apolipoprotein B(Apo B)levels increased,the risk of high Lp(a)increased,with OR(95％CI)for each elevated group was 2.40(1.76-3.24),2.68(1.36-4.93),1.29(1.03-1.61),and 1.65(1.27-2.13),respectively.The risk of high Lp(a)was reduced in the HDL-C lowering group with an OR(95％CI)of 0.76(0.61-0.94).In contrast,an increase in TG levels and the ratio of Apo A1/Apo B(Apo A1/B)was negatively correlated with the risk of high Lp(a),with OR(95％CI)of 0.73(0.60-0.89)for elevated triglyceride group,and OR(95％CI)of 0.60(0.50-0.72)for the Apo A1/B ratio increase group(linear trend test P≤0.001 except for Apo A1).However,no correlation was found between Lp(a)levels and lifestyle factors such as diet,smoking,and physical activity.Conclusions Lp(a)levels were associated with sex and abdominal obesity,but less with lifestyle behaviors.
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