首页|苏州市成年人睡眠状况与冠心病发病风险的前瞻性关联研究

苏州市成年人睡眠状况与冠心病发病风险的前瞻性关联研究

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目的 探讨苏州市成年人睡眠状况与冠心病发病的关联.方法 使用中国慢性病前瞻性研究苏州市吴中区项目点53 269例30～79岁调查对象的基线和随访信息,剔除基线调查时自报患有冠心病、脑卒中、癌症的研究对象后,最终纳入分析51 929例研究对象.采用Cox比例风险回归模型分析各睡眠因素(打鼾症状、失眠症状、每日睡眠时长、午睡情况)、健康睡眠评分(0～3分)与冠心病发病风险的关联.结果 研究对象中位随访时间为11.12年,随访期间共诊断冠心病1304例.调整潜在混杂因素后,与没有相应睡眠症状者相比,有时打鼾(HR=1.20,95％CI:1.04～1.38)、经常打鼾(HR=1.17,95％CI:1.02～1.33)、有失眠障碍(HR=1.41,95％CI:1.12～1.78)、日间功能障碍(HR=1.56,95％CI:1.20～2.03)、常年午睡(HR=1.37,95％CI:1.19～1.59)均与冠心病发病风险增加相关.与健康睡眠评分为0～1分(睡眠最不健康)者相比,健康睡眠评分3分(睡眠最健康)者冠心病发病风险降低26％(HR=0.74,95％CI:0.63～0.87).分层分析结果显示,健康睡眠评分3分与冠心病发病风险的关联在低体力活动水平亚组中更明显(交互作用P＜0.05).结论 打鼾、失眠障碍、日间功能障碍、常年午睡均与冠心病发病风险增加相关,遵循健康的睡眠模式也许可以降低成年人冠心病发病风险.
Prospective association study of sleep status and risk of coronary heart disease in adults in Suzhou
Objective To investigate the association between sleep status and the risk for coronary heart disease in adults in Suzhou.Methods Using the baseline and follow up information of 53 269 local residents aged 30-79 years in China Kadoorie Biobank conducted in Wuzhong District,Suzhou,51 929 subjects were included in this study after excluding those reporting coronary heart disease,stroke and cancer at the baseline survey.A Cox proportional hazards regression model was used to analyze the association of healthy sleep score(0-3 points)and sleep factors(snoring,insomnia,long sleep duration and nap)with the risk for coronary heart disease.Results The median follow-up time was 11.12 years,and 1 304 individuals were diagnosed with coronary heart disease during the follow-up.After adjusting for potential confounders,occasional snoring(HR=1.20,95％CI:1.04-1.38),usual snoring(HR=1.17,95％CI:1.02-1.33),insomnia disorder(HR=1.41,95％CI:1.12-1.78),daytime dysfunction(HR=1.56,95％CI:1.20-2.03)and perennial nap(HR=1.37,95％CI:1.19-1.59)were associated with increased risk of coronary heart disease.Compared with those with sleep score of 0-1(low sleep quality),the people with sleep score of 3 had reduced risk of coronary heart disease by 26％(HR=0.74,95％CI:0.63-0.87).Stratified analysis showed that the association of healthy sleep score 3 with risk of coronary heart disease was stronger in low physically active individuals(interaction P＜0.05).Conclusions Snoring,insomnia disorders,daytime dysfunction,and perennial napping were all associated with increased risk for coronary heart disease,and keep healthy sleep mode might reduce the risk for coronary heart disease in adults.

Sleep statusCoronary heart diseaseProspective study

华姜、范习康、苏健、陈路路、陆艳、华钰洁、任洪福、裴培、孙点剑一、余灿清、吕筠、周金意、陶然

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南京医科大学公共卫生学院,南京 211166

江苏省疾病预防控制中心慢性非传染病防制所,南京 210009

苏州市疾病预防控制中心慢性非传染病防制科,苏州 215004

苏州市吴中区疾病预防控制中心,苏州 215128

北京大学公众健康与重大疫情防控战略研究中心,北京 100191

北京大学公共卫生学院流行病与卫生统计学系,北京 100191

重大疾病流行病学教育部重点实验室(北京大学),北京 100191

血管稳态与重构全国重点实验室,北京 100191

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睡眠状况 冠心病 前瞻性研究

国家自然科学基金国家自然科学基金国家自然科学基金国家自然科学基金国家自然科学基金国家重点研发计划"精准医学研究"重点专项中国香港Kadoorie Charitable基金英国Wellcome Trust英国Wellcome Trust英国Wellcome Trust江苏省卫生健康委员会医学科研项目江苏省卫生健康委员会医学科研项目

82192900821929018219290481390540918463032016YFC0900500202922/Z/16/Z088158/Z/09/Z104085/Z/14/ZM2020085H2023022

2024

10.3760/cma.j.cn112338-20231215-00356

中华流行病学杂志
中华医学会

中华流行病学杂志

CSTPCD北大核心
影响因子：1.985
ISSN：0254-6450
年,卷(期)：2024.45(7)
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