母亲孕期吸烟及子代遗传风险与全肿瘤死亡风险的队列研究
A cohort study of maternal smoking during pregnancy,offspring genetic risk,and overall cancer mortality
庞官连 1马志敏 1诸铭轩 1葛文静 1牟园淋 1王国庆 1朱兆鹏 1李樵 1朱猛2
作者信息
- 1. 南京医科大学公共卫生学院流行病学系,南京 211166
- 2. 南京医科大学公共卫生学院流行病学系,南京 211166;南京医科大学省部共建肿瘤个体化医学协同创新中心,南京 211166
- 折叠
摘要
目的 探讨母亲孕期吸烟和子代遗传易感性对全肿瘤死亡风险的独立和综合影响.方法 基于英国生物银行(n=419 228)数据,使用Cox比例风险回归模型估计母亲孕期吸烟对子代全肿瘤(包括男性16种和女性18种恶性肿瘤)死亡风险的影响,并分析母亲孕期吸烟与子代遗传因素的联合效应和交互作用.结果 母亲孕期吸烟与子代全肿瘤死亡风险的增加显著相关,其中男性增加13％[风险比(HR)=1.13,95％CI:1.06～1.20],女性增加 19％(HR=1.19,95％CI:1.11～1.27).与低遗传风险者相比,高遗传风险者的全肿瘤死亡风险最高(男性:HR=1.42,95％CI:1.30～1.55;女性:HR=1.38,95％CI:1.25～1.52).与母亲孕期未吸烟、低遗传风险的参与者相比,母亲孕期吸烟且高遗传风险的男性全肿瘤死亡风险增加 56％(HR=1.56,95％CI:1.37～1.77),女性增加 59％(HR=1.59,95％CI:1.39～1.83).结论 母亲孕期吸烟可能会增加子代的全肿瘤死亡风险,且在高遗传风险的个体中母亲孕期吸烟的危害更严重.
Abstract
Objective To investigate the independent and combined effects of maternal smoking during pregnancy and offspring genetic susceptibility on overall cancer mortality.Methods Based on the United Kingdom Biobank(n=419 228)data,the Cox proportional hazard regression model was used to estimate the effect of maternal smoking during pregnancy on offspring overall cancer(including 16 cancers in men and 18 in women)mortality and its combined effect and interaction with offspring genetic factors.Results Maternal smoking during pregnancy was significantly associated with a 13％increased risk of overall cancer mortality in men[hazard ratio(HR)=1.13,95％CI:1.06-1.20]and 19％increased risk in women(HR=1.19,95％CI:1.11-1.27).Participants with high genetic risk had the highest overall cancer mortality than those with low genetic risk(men:HR=1.42,95％CI:1.30-1.55;women:HR=1.38,95％CI:1.25-1.52).Compared with participants without maternal smoking during pregnancy and low genetic risk,those with maternal smoking during pregnancy and high genetic risk were associated with a 56％increased risk of overall cancer mortality in men(HR=1.56,95％CI:1.37-1.77)and 59％in women(HR=1.59,95％CI:1.39-1.83).Conclusion Maternal smoking during pregnancy may increase offspring overall cancer mortality and more severe harm in individuals with high genetic risk.
关键词
母亲孕期吸烟/多基因风险评分/全肿瘤死亡风险/前瞻性队列研究Key words
Maternal smoking during pregnancy/Polygenic risk score/Overall cancer mortality/Prospective cohort study引用本文复制引用
基金项目
江苏省优秀青年基金(BK20220100)
英国生物银行项目(82535)
出版年
2024
NETL
NSTL
万方数据