目的 分析绝经前后空腹血糖水平的变化趋势。 方法 采用队列研究的方法，以参加开滦体检队列首次体检并在第7次体检结束时获得绝经年龄的≥18岁女性为研究对象，共纳入3 749例女性的22 057人次体检记录进行分析。将空腹血糖(FPG)进行自然对数转换，采用分段线性混合效应模型方法分析绝经前后lnFPG的变化，进一步分析基线年龄和基线体重指数(BMI)与绝经前后时间对lnFPG的相乘交互作用。 结果 本研究女性的首次体检平均年龄为(45.63±4.52)岁，中位绝经年龄为51(50～53)岁，体检次数的中位数为6(5～7)次。分段线性混合效应模型结果显示，LnFPG从绝经前1年开始增加，平均年增长量为0.021 mmol/L；在绝经至绝经后5年持续增加，平均年增长量降为0.007 mmol/L；在绝经5年以后，LnFPG趋于平稳。基线年龄会影响lnFPG在绝经前后的变化，基线年龄≥45岁与绝经前6年至绝经前1年的时间分段对lnFPG有负向交互作用(P＝0.032)，基线年龄≥45岁的女性在绝经前1年至绝经后5年，LnFPG的年平均增长量均高于基线年龄<45岁的女性(均P<0.05)。基线BMI与绝经前后时间对lnFPG有正向相乘交互作用，即肥胖女性在绝经前6年至绝经前1年和绝经至绝经后5年这2个时间分段，LnFPG的年平均增长量均高于基线BMI<24 kg/m2的女性(均P<0.05)。 结论 绝经对FPG会产生不良影响，不良变化主要发生在绝经前1年至绝经后5年，年龄和BMI会影响绝经前后FPG的变化。 Objective To analyze the changes of fasting plasma glucose(FPG)level before and after menopause. Methods Kailuan health checkup cohort was used to extract data of women aged≥18 years who participated in the first physical examination of Kailuan physical examination cohort and had menopausal age at the end of the seventh physical examination. A total of 3 749 women with 22 057 physical examination records were included in the analysis. Natural logarithmic transformation was applied to FPG, and a segmented linear mixed-effects model was used to analyze the changes in ln-transformed FPG before and after menopause. Additionally, an interaction analysis was performed to assess the multiplicative effect of baseline age and baseline body mass index(BMI)on ln-transformed FPG concerning pre- and post-menopausal periods. Results The average age of the first physical examination for women in this study was (45.63±4.52)years, the median menopausal age was 51(50~53)years, and the median number of physical examinations was 6(5~7)times. The results of the piecewise linear mixed effect model showed that lnFPG increased from 1 year before menopause, with an average annual increase of 0.021 mmol/L, and continued to increase from menopause to 5 years after menopause, with an average annual increase of 0.007 mmol/L. LnFPG tended to be stable after 5 years of menopause. Baseline age could affect the changes of lnFPG before and after menopause, and there was a negative multiplicative interaction between baseline age ≥45 years and the time period from 6 years to 1 year before menopause(P=0.032). Women with baseline age ≥45 years had a higher average annual increase in lnFPG from 1 year before menopause to 5 years after menopause than women with baseline age <45 years( P<0.05). On lnFPG, there was a positive multiplicative interaction between baseline BMI and time segments around menopause. Compared to women with BMI <24.0 kg/m2, obese women displayed more annual increase in lnFPG from 6 years to 1 year before menopause as well as from menopause to 5 years after menopause(P<0.05). Conclusions Menopause has an adverse impact on FPG, with the most significant changes occurring within the period of one year before menopause and up to five years after menopause. Age and BMI significantly influence the changes in FPG before and after menopause.
Changes of fasting plasma glucose level before and after menopause: Research based on Kailuan health checkup cohort
Objective To analyze the changes of fasting plasma glucose(FPG)level before and after menopause. Methods Kailuan health checkup cohort was used to extract data of women aged≥18 years who participated in the first physical examination of Kailuan physical examination cohort and had menopausal age at the end of the seventh physical examination. A total of 3 749 women with 22 057 physical examination records were included in the analysis. Natural logarithmic transformation was applied to FPG, and a segmented linear mixed-effects model was used to analyze the changes in ln-transformed FPG before and after menopause. Additionally, an interaction analysis was performed to assess the multiplicative effect of baseline age and baseline body mass index(BMI)on ln-transformed FPG concerning pre- and post-menopausal periods. Results The average age of the first physical examination for women in this study was (45.63±4.52)years, the median menopausal age was 51(50~53)years, and the median number of physical examinations was 6(5~7)times. The results of the piecewise linear mixed effect model showed that lnFPG increased from 1 year before menopause, with an average annual increase of 0.021 mmol/L, and continued to increase from menopause to 5 years after menopause, with an average annual increase of 0.007 mmol/L. LnFPG tended to be stable after 5 years of menopause. Baseline age could affect the changes of lnFPG before and after menopause, and there was a negative multiplicative interaction between baseline age ≥45 years and the time period from 6 years to 1 year before menopause(P=0.032). Women with baseline age ≥45 years had a higher average annual increase in lnFPG from 1 year before menopause to 5 years after menopause than women with baseline age <45 years( P<0.05). On lnFPG, there was a positive multiplicative interaction between baseline BMI and time segments around menopause. Compared to women with BMI <24.0 kg/m2, obese women displayed more annual increase in lnFPG from 6 years to 1 year before menopause as well as from menopause to 5 years after menopause(P<0.05). Conclusions Menopause has an adverse impact on FPG, with the most significant changes occurring within the period of one year before menopause and up to five years after menopause. Age and BMI significantly influence the changes in FPG before and after menopause.
MenopauseFasting plasma glucoseCohort studyBody mass index
万方数据
