多囊卵巢综合征(PCOS)的主要特征是雄激素过多和排卵障碍。PCOS不仅影响育龄期女性的生殖健康，而且作为一种代谢性疾病增加患者的长期健康风险。PCOS的发病机制尚不完全明确。早发现、早诊断、早治疗对于PCOS患者的预后非常重要。近期，BMJ Medicine就这一问题发表了1篇题为《多囊卵巢综合征：病理生理学和治疗机遇》的综述[Dong J, Rees DA. Polycystic ovary syndrome: pathophysiology and therapeutic opportunities. BMJ Medicine, 2023，2(1): e000548]。该文为开放获取文章，本文对其进行了中文编译。该综述汇总相关文献，就PCOS关键病理生理过程进行了深入的阐释和探讨，对目前现有药物进行总结，并对新兴药物的治疗进行了回顾与展望。 Polycystic ovary syndrome(PCOS) is characterized by excessive androgen levels and ovulatory dysfunction. Beyond its impact on the reproductive wellness of women of reproductive age, PCOS poses long-term health risks as a metabolic disease. The pathogenesis of PCOS is not fully understood. Early detection, diagnosis, and treatment are crucial for the prognosis of patients with PCOS. A review "Polycystic ovary syndrome: pathophysiology and therapeutic opportunities" was recently published in BMJ Medicine [Dong J, Rees DA. Polycystic ovary syndrome: pathophysiology and therapeutic opportunities. BMJ Medicine, 2023, 2(1): e000548]. This open-access article has been translated into Chinese. The review consolidates relevant literature, offers a comprehensive exploration of the key pathophysiology of PCOS, evaluates existing treatment modalities, and concludes by highlighting therapeutic opportunities presented by emerging drugs.
Recent advance in the pathogenesis and treatment of polycystic ovary syndrome
Polycystic ovary syndrome(PCOS) is characterized by excessive androgen levels and ovulatory dysfunction. Beyond its impact on the reproductive wellness of women of reproductive age, PCOS poses long-term health risks as a metabolic disease. The pathogenesis of PCOS is not fully understood. Early detection, diagnosis, and treatment are crucial for the prognosis of patients with PCOS. A review "Polycystic ovary syndrome: pathophysiology and therapeutic opportunities" was recently published in BMJ Medicine [Dong J, Rees DA. Polycystic ovary syndrome: pathophysiology and therapeutic opportunities. BMJ Medicine, 2023, 2(1): e000548]. This open-access article has been translated into Chinese. The review consolidates relevant literature, offers a comprehensive exploration of the key pathophysiology of PCOS, evaluates existing treatment modalities, and concludes by highlighting therapeutic opportunities presented by emerging drugs.
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