Correlation between fat distribution and the composite indices of femoral neck strength in obese postmenopausal women
张万丽 1王金娣 2路迪迪 1刘盼 3周文斌 4徐晶晶 1何畏 1朱鋐达
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作者信息
1. 南京医科大学第一附属医院内分泌科，南京 210029
2. 丹阳市练湖社区医院骨质疏松科，丹阳 212300
3. 南京市高淳人民医院康复医学科，南京 211300
4. 南京医科大学第一附属医院乳腺外科，南京 210029
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摘要
目的 探讨肥胖绝经后女性脂肪分布与股骨颈强度综合指数相关性。 方法 选取非低体重绝经后女性293例，完善实验室检查、人体成分分析仪以及双能X线骨吸收仪检查，根据体重指数(body mass index, BMI)将研究对象分为正常BMI组(18.5 kg/m2≤BMI<24.0 kg/m2, 91例)、超重组(24.0 kg/m2≤BMI<28.0 kg/m2, 115例)和肥胖组(BMI≥28.0 kg/m2, 87例)，并对测量结果进行分析研究。 结果 绝经后女性肥胖组所有部位骨密度(bone mineral density, BMD)均高于正常BMI组和超重组(P<0.005)，肥胖组压缩强度指数(compression strength index, CSI)，弯曲强度指数(bending strength index, BSI)和冲击强度指数(impact strength index, ISI)均显著低于正常BMI组(P<0.001,P＝0.008, P＝0.001)。肥胖组中腰围、腰臀比、总脂肪量、四肢脂肪量、躯干脂肪量是CSI、BSI和ISI独立于年龄、空腹血糖、BMI的危险因素(P<0.05)。内脏脂肪等级与中国内脏脂肪指数是LSI、BSI和ISI的危险因素(P<0.05)。 结论 绝经后肥胖女性股骨颈强度综合指数降低，此人群皮下脂肪与内脏脂肪均与股骨颈强度综合指数负相关。 Objective To investigate the correlation between fat distribution and the composite indices of femoral neck strength in obese postmenopausal women. Methods A total of 293 postmenopausal women with non-low body weight were selected, laboratory tests, body composition analyzer test and double-energy X-ray absorptiometry scan were performed. Based on the body mass index(BMI), they were divided into three groups, the normal BMI group(18.5 kg/m2≤BMI<24.0 kg/m2, n=91), the overweight group(24.0 kg/m2≤BMI<28.0 kg/m2, n=115), and the obese group(BMI≥28.0 kg/m2, n=87). The measurement results were analyzed. Results In the obese group, bone mineral density(BMD) of all sites was higher than that in the normal BMI group and overweight group(P<0.005), compression strength index(CSI), bending strength index(BSI), and impact strength index(ISI) were significantly lower than those in the normal BMI group(P<0.001,P=0.008, P=0.001). In the obese group, waist circumference, waist-hip ratio, total fat mass, appendicular fat mass, and trunk fat mass were risk factors for CSI, BSI and ISI independent of age, fasting blood glucose, and BMI(P<0.05). Visceral fat grade and Chinese visceral adiposity fat index were the risk factors for CSI, BSI, and ISI(P<0.05). Conclusion The composite indices of femoral neck strength decreased in obese postmenopausal women, and both subcutaneous fat and visceral fat were negatively associated with the composite indices of femoral neck strength.
Abstract
Objective To investigate the correlation between fat distribution and the composite indices of femoral neck strength in obese postmenopausal women. Methods A total of 293 postmenopausal women with non-low body weight were selected, laboratory tests, body composition analyzer test and double-energy X-ray absorptiometry scan were performed. Based on the body mass index(BMI), they were divided into three groups, the normal BMI group(18.5 kg/m2≤BMI<24.0 kg/m2, n=91), the overweight group(24.0 kg/m2≤BMI<28.0 kg/m2, n=115), and the obese group(BMI≥28.0 kg/m2, n=87). The measurement results were analyzed. Results In the obese group, bone mineral density(BMD) of all sites was higher than that in the normal BMI group and overweight group(P<0.005), compression strength index(CSI), bending strength index(BSI), and impact strength index(ISI) were significantly lower than those in the normal BMI group(P<0.001,P=0.008, P=0.001). In the obese group, waist circumference, waist-hip ratio, total fat mass, appendicular fat mass, and trunk fat mass were risk factors for CSI, BSI and ISI independent of age, fasting blood glucose, and BMI(P<0.05). Visceral fat grade and Chinese visceral adiposity fat index were the risk factors for CSI, BSI, and ISI(P<0.05). Conclusion The composite indices of femoral neck strength decreased in obese postmenopausal women, and both subcutaneous fat and visceral fat were negatively associated with the composite indices of femoral neck strength.
关键词
肥胖/绝经后女性/骨强度/股骨颈强度综合指数/脂肪分布/皮下脂肪/内脏脂肪
Key words
Obesity/Postmenopausal women/Bone strength/Composite indices of femoral neck strength/Fat distribution/Subcutaneous fat/Visceral fat
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