Gut microbiota and immune mechanism of type 1 diabetes mellitus
张冰 1方圆圆 1王玉莹 1袁慧娟 1朱梅华
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作者信息
1. 郑州大学人民医院（河南省人民医院）内分泌与代谢病科，郑州 450003
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摘要
1型糖尿病是一种T细胞介导的好发于青少年的自身免疫性疾病，以胰岛β细胞进行性破坏、胰岛素绝对缺乏、高血糖为主要特征。1型糖尿病的发病机制较为复杂，目前认为其主要与免疫、环境、遗传有关。越来越多的证据表明，肠道菌群与1型糖尿病的发生密切相关。本文从固有免疫和适应性免疫角度，重点探讨了肠道菌群及其衍生物在1型糖尿病发生发展中的相关免疫机制和作用，并介绍了以肠道菌群为靶点治疗1型糖尿病的方法。 Type 1 diabetes mellitus is a T-cell-mediated autoimmune disease that commonly affects adolescents, characterized by progressive destruction of pancreatic β-cells, absolute insulin deficiency, and hyperglycemia. The pathogenesis of type 1 diabetes mellitus is complex and is believed to be mainly associated with immunity, environment, and genetics. There is increasing evidence that gut microbiota is closely related to the occurrence of type 1 diabetes mellitus. This article focuses on the immune mechanisms and roles of gut microbiota and its derivatives in the development of type 1 diabetes mellitus from the perspectives of innate and adaptive immunity. Additionally, it introduces therapeutic approaches targeting gut microbiota for the treatment of type 1 diabetes mellitus.
Abstract
Type 1 diabetes mellitus is a T-cell-mediated autoimmune disease that commonly affects adolescents, characterized by progressive destruction of pancreatic β-cells, absolute insulin deficiency, and hyperglycemia. The pathogenesis of type 1 diabetes mellitus is complex and is believed to be mainly associated with immunity, environment, and genetics. There is increasing evidence that gut microbiota is closely related to the occurrence of type 1 diabetes mellitus. This article focuses on the immune mechanisms and roles of gut microbiota and its derivatives in the development of type 1 diabetes mellitus from the perspectives of innate and adaptive immunity. Additionally, it introduces therapeutic approaches targeting gut microbiota for the treatment of type 1 diabetes mellitus.
关键词
糖尿病,1型/肠道菌群/免疫机制
Key words
Diabetes mellitus, type 1/Gut microbiota/Immune mechanism
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