摘要
目的:了解男性肿瘤患者精液质量现状,探索保存男性肿瘤患者生育能力的方法. 方法:对来源于2005～2013年浙江省人类精子库43例肿瘤自精保存患者的精液质量进行回顾性分析,检测项目包括精液体积、精子浓度、精子活力、精子冷冻复苏率等指标.比较肿瘤患者与供精志愿者(248例)之间精液质量的差异;并将肿瘤患者分为睾丸肿瘤组(22例)和非睾丸肿瘤组(21例),比较两组之间精液质量的差异. 结果:43例肿瘤患者精液的平均精子浓度(60.90×106/ml)、前向运动精子百分率(41.07％)及精子冷冻复苏率(49.98％)均显著低于供精志愿者(分别为74.27×106/ml、51.79％和57.33％),P均＜0.05;睾丸肿瘤组的冻后平均前向运动精子百分率(15.68％)与冷冻复苏率(42.81％)均显著低于非睾丸肿瘤组(分别为28.36％和57.53％),P均＜0.05. 结论:肿瘤患者精液质量普遍下降,进行自精保存的时机非常重要,应该加强自精保存的宣传力度.另外,睾丸肿瘤患者精液冷冻保存效果较差,精子库应对其冷冻复苏率低下的原因进行深入研究,优化冷冻保存技术,为患者提供更好的生育力保护.
Abstract
Objective:To investigate the semen quality of cancer patients and search for a better way of sperm cryopreservation for them.Methods:We retrospectively analyzed the quality of the semen from 43 cancer patients under cryopreservation in the Sperm Bank of Zhejiang Province,and compared the semen parameters between the cancer patients and 248 normal donors as well as between the testicular cancer cases (n =22) and non-testicular cancer cases (n =21).Results:The cancer patients exhibited significantlylower semen quality than the normal donors as in sperm concentration (60.90 × 106/ml vs 74.27 × 106/ml),progressive motility (41.07％ vs 51.79％),and recovery rate (49.98 ％ vs 57.33 ％) (all P ＜ 0.05).Furthermore,the progressive sperm motility and sperm recovery rate after freezing were significantly decreased in the testicular cancer cases (15.68％ and 42.81％) than in the nontesticular cancer cases (28.36％ and 57.53％) (both P ＜ 0.05).Conclusion:Semen quality declines in cancer patients,and therefore early sperm cryopreservation is essential for them.Due to the poor sperm motility and recovery rate of testicular cancer patients after freezing,further investigation is required on the improvement of sperm cryopreservation methods.
NETL
NSTL
维普
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