细胞焦亡在前列腺癌发展中的作用研究进展
Pyroptosis in the development and progression of prostate cancer:Progress in research
赵琦 1左康为 1李卫平2
作者信息
- 1. 兰州大学第一临床医学院,甘肃兰州 730000
- 2. 兰州大学第一医院泌尿外科,甘肃兰州 730000
- 折叠
摘要
细胞焦亡作为一种新的程序性死亡方式,其在前列腺癌发生与发展中有重要作用,而且针对细胞焦亡途径的靶向药物可以作为一种新的治疗方式在未来起到极大的影响,但是细胞焦亡的具体机制仍然还不明确,因此还需大量研究进行深入探索.本文就近几年来细胞焦亡在前列腺癌中的作用作一综述,主要包括焦亡的发生机制、其在前列腺癌发生发展中的作用及其临床应用,为临床工作者提供一个新的治疗及药物研发策略.
Abstract
Pyroptosis,as a new programmed death mode,plays an important role in the development and progression of prostate cancer,and the drugs targeting the pyroptosis pathway,as a new therapeutic strategy,may produce a significant influence on the treat-ment of prostate cancer.However,the precise mechanism of cellular pyroptosis remains unclear,necessitating further investigation.This paper presents a summary of the role of cellular pyroptosis in prostate cancer over recent years.It includes a discussion of the mechanism of pyroptosis,its role in prostate cancer development,and its clinical applications.This will provide clinicians with a new strategy for treatment and drug development.
关键词
细胞焦亡/前列腺癌/细胞死亡/靶向策略Key words
pyroptosis/prostate cancer/cell death/target therapy引用本文复制引用
基金项目
甘肃省自然科学基金(22JR5RA912)
出版年
2024
NETL
NSTL
万方数据