两样本双向孟德尔随机化研究抑郁症与压力性尿失禁之间的因果关联
Causal association between depression and stress urinary incontinence:A two-sample bidirectional Mendelian randomization study
姜程校 1殷玮琪 1许晶晶 2史颖姣 2王力 2郑智博 2苏瑞 1胡勤波 2钱君海 1孙树本1
作者信息
- 1. 宁波大学附属第一医院泌尿外科,浙江宁波 315010
- 2. 宁波大学附属第一医院生殖医学中心,浙江宁波 315010
- 折叠
摘要
目的:采用两样本孟德尔随机化(MR)分析方法,探讨抑郁症与压力性尿失禁之间的因果关联.方法:抑郁症全基因组关联研究(GWAS)数据来自于芬兰数据库,共收集了 192 220例对照样本和23 424例病例样本.压力性尿失禁的GWAS数据由英国生物银行提供,包括4 340例病例样本和458 670例对照样本.为了进一步验证抑郁症与压力性尿失禁之间的相关性,还使用了来自精神病学基因组学联盟(PGC)的抑郁症数据.在MR研究中,以逆方差加权(IVW)为主要的分析方法.此外,为了确保研究结果的准确性及稳定性还进行了敏感性分析.结果:使用来自英国生物银行和芬兰数据库的数据分析结果显示,抑郁症与压力性尿失禁风险增加之间存在相关性(P=0.005).相反,压力性尿失禁与抑郁症风险无相关性(P=0.927).采用PGC数据库分析验证结果显示,抑郁症和压力性尿失禁风险增加之间存在相关性(P=0.043).结论:抑郁症可导致压力性尿失禁患病风险增加,而压力性尿失禁并不影响抑郁症患病风险.
Abstract
Objective:To investigate the causal correlation between depression and stress urinary incontinence(SUI)using Mendelian randomization(MR)analysis.Methods:We searched the FinnGen Consortium database for genome-wide association studies(GWAS)on depression and obtained 23 424 case samples and 192 220 control samples,with the GWAS data on SUI provided by the UK Biobank,including 4 340 case samples and 458 670 control samples.We investigated the correlation between depression and SUI based on the depression data collected from the Psychiatric Genomics Consortium(PGC).We employed inverse-variance weighting as the main method for the MR study,and performed sensitivity analysis to verify the accuracy and stability of the findings.Results:Analysis of the data from the UK Biobank and FinnGen Consortium showed that depression was significantly correlated with an increased risk of SUI(P=0.005),but not SUI with the risk of depression(P=0.927).And analysis of the PGC data verified the correlation of depression with the increased risk of SUI(P=0.043).Conclusion:Depression is associated with an increased risk of SUI,while SUI does not increase the risk of depression.
关键词
压力性尿失禁/抑郁症/孟德尔随机化/因果推断Key words
stress urinary incontinence/depression/Mendelian randomization/causal association引用本文复制引用
基金项目
宁波市医疗卫生高端团队重大攻坚项目(2022020230)
宁波市泌尿系疾病临床医学研究中心(2019A21001)
浙江省医药卫生科技计划项目(2020KY251)
出版年
2024
NETL
NSTL
万方数据