前列腺癌局灶治疗的研究进展
Focal therapy for prostate cancer:Progress in research
柏靖星 1黄引 1曹德宏 1柳良仁1
作者信息
- 1. 四川大学华西医院泌尿外科,四川成都 610041
- 折叠
摘要
前列腺癌是全世界男性中第二常见的肿瘤性疾病,并且其发病率仍呈现逐步上升的趋势.大部分前列腺癌患者都采用根治性前列腺切除术的方式进行治疗,不过随着影像学的发展和理论技术的创新,前列腺癌局灶治疗表现出了更好的应用前景.与根治性前列腺切除术相比,前列腺癌局灶治疗具有良好的疗效和较少的并发症,并且可以避免过度治疗和降低疾病治疗的经济负担.本文通过分析近年来前列腺癌局灶治疗的临床试验,对冷冻消融、高强度聚焦超声、不可逆电穿孔、光动力疗法在内的局灶治疗方法作一综述.
Abstract
Prostate cancer(PCa)is currently the second most common malignancy in men worldwide,and its incidence rate is on the rise.Most cases of PCa are treated by radical prostatectomy,but with the development of medical imaging and innovation in therapeutic theories and technology,focal therapy has shown better application prospects in the treatment of PCa.Compared with radi-cal prostatectomy,focal therapy yields satisfactory results in terms of effectiveness and reduction of complications in addition to avoid-ance of overtreatment and treatment-related financial burden.This article reviews the strategies of focal therapy for PCa,including cryo-ablation,high-intensity focused ultrasound,irreversible electroporation,and photodynamic therapy,with an analysis of the clinical tri-als in recent years.
关键词
前列腺癌/局灶治疗/冷冻消融/高强度聚焦超声/不可逆电穿孔/光动力疗法Key words
prostate cancer/focal therapy/cryoablation/high-intensity focused ultrasound/irreversible electroporation/photo-dynamic therapy引用本文复制引用
基金项目
国家自然科学基金(81200551)
国家重点研发计划(2022YFC3602905)
出版年
2024
NETL
NSTL
万方数据