Peripheral blood lymphocyte subsets are associated with the prognosis of prostate cancer
Objective:To explore the relationship between peripheral lymphocyte subsets and the survival of PCa patients.Methods:Using the Kaplan-Meier curve and log-rank test,we compared the overall survival(OS)and progression-free survival(PFS)of 100 PCa patients with different levels of lymphocytes.Meanwhile,we investigated the prognostic factors by univariate and multivariate Cox regression analyses,and counted the peripheral lymphocyte subsets by flow cytometry.Results:Both OS and PFS were significantly prolonged in the PCa patients with high levels of lymphocytes(≥747/μl),CD3+T cells(≥528/μl),CD4+T cells(≥315/μl),CD8+T cells(≥226/μl),B cells(≥105/μl)and NK cells(≥168/μl)(P<0.001).Univariate and multivariate Cox regression analyses indicated that CD4+T cells≤315/μl was an independent factor for the poor prognosis of PCa(HR=12.58,95%CI:3.00-52.73).Conclusion:Decreased absolute count of peripheral lymphocyte subsets is associated with the poor progno-sis of PCa.
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