免疫细胞亚群与前列腺癌患者预后的关联性研究
Peripheral blood lymphocyte subsets are associated with the prognosis of prostate cancer
茆飞 1杨超 1冀鲁1
作者信息
- 1. 南京医科大学附属淮安第一医院泌尿外科,江苏 淮安 223300
- 折叠
摘要
目的:探讨外周淋巴细胞亚群与前列腺癌(PCa)患者生存之间的关系.方法:本研究纳入了100例PCa患者,采用Kaplan-Meier曲线和log-rank检验比较不同淋巴细胞水平PCa患者总生存期(OS)和无进展生存期(PFS);同时,通过单因素和多因素Cox回归分析来探索预后的影响因素.外周淋巴细胞亚群的计数采用流式细胞术进行.结果:在淋巴细胞≥747/μl、CD3+T细胞≥528/μl、CD4+T细胞≥315/μl、CD8+T细胞≥226/μl、B细胞≥105/μl、NK细胞≥168/μl的PCa患者中,OS和PFS显著延长(P<0.01).单因素和多因素Cox回归分析表明,CD4+T细胞≤315/μl是PCa患者不良预后的独立因素(HR=12.58,95%CI,3.00～52.73).结论:本研究揭示了外周淋巴细胞亚群绝对计数较低与PCa患者不良预后相关.
Abstract
Objective:To explore the relationship between peripheral lymphocyte subsets and the survival of PCa patients.Methods:Using the Kaplan-Meier curve and log-rank test,we compared the overall survival(OS)and progression-free survival(PFS)of 100 PCa patients with different levels of lymphocytes.Meanwhile,we investigated the prognostic factors by univariate and multivariate Cox regression analyses,and counted the peripheral lymphocyte subsets by flow cytometry.Results:Both OS and PFS were significantly prolonged in the PCa patients with high levels of lymphocytes(≥747/μl),CD3+T cells(≥528/μl),CD4+T cells(≥315/μl),CD8+T cells(≥226/μl),B cells(≥105/μl)and NK cells(≥168/μl)(P<0.001).Univariate and multivariate Cox regression analyses indicated that CD4+T cells≤315/μl was an independent factor for the poor prognosis of PCa(HR=12.58,95%CI:3.00-52.73).Conclusion:Decreased absolute count of peripheral lymphocyte subsets is associated with the poor progno-sis of PCa.
关键词
淋巴细胞亚群/前列腺癌/生存/CD4+T细胞/NK细胞Key words
lymphocyte subsets/prostate cancer/survival/CD4+T cells/NK cells引用本文复制引用
出版年
2024
NETL
NSTL
万方数据