基因修饰干细胞治疗阴茎勃起功能障碍的研究进展
Progress in gene-modified stem cell therapy for penile erectile dysfunction
胡道远 1肖恒军2
作者信息
- 1. 中山大学附属第三医院泌尿外科,广东 广州 510630;中山大学附属第六医院泌尿外科,广东 广州 510655
- 2. 中山大学附属第三医院泌尿外科,广东 广州 510630
- 折叠
摘要
勃起功能障碍(ED)是常见的男科疾病,缺乏满意的治疗方法.干细胞(SC)具有自我更新及多向分化潜能,可分泌多种活性物质,是再生医学领域研究的重点.SC治疗ED具有广阔的应用前景,然而,由于ED的复杂性及SC的局限性,单纯SC治疗ED效果有限.基因修饰可从多维度提升SC性能,发挥靶基因功能,较单纯SC治疗可更显著改善勃起功能及相应病理变化,近年来已成为男科学领域的研究热点.本文综述基因修饰干细胞治疗ED的相关研究,期望为后续探索提供思路.
Abstract
Erectile dysfunction(ED)is a common disorder in men and lacks effective treatment.Stem cell(SC)possess the potential in self-renewal and multi-directional differentiation,and secrete a variety of active substances.Stem cell therapy,as a promis-ing option for the treatment of ED,is a focus in regenerative medicine research.However,the effect of stem cell therapy alone on ED is limited due to the complexity of the condition and the limitations of SC.Gene modification can enhance the performance of SC in multiple aspects and play the role of targeted genes,and therefore can better improve ED and its related pathological changes than SC therapy alone.In recent years,gene-modified stem cell therapy has become a hotspot in andrological research.This review summarizes the advances in the studies of gene-modified SC in the treatment of ED,aiming to provide some ideas for further research.
关键词
干细胞/勃起功能障碍/基因修饰Key words
stem cell/erectile dysfunction/gene modification引用本文复制引用
基金项目
国家自然科学基金面上项目(81771573)
广州市院联合资助项目(2024A03J0275)
出版年
2024
NETL
NSTL
万方数据