中药调控铁死亡途径干预睾丸生精上皮损伤的研究进展
Intervention of traditional Chinese medicine in spermatogenic epithelium injury by regulating the ferroptosis pathway:Advances in studies
魏锦涛 1马紫阳 1曹军 2张培海1
作者信息
- 1. 成都中医药大学附属医院泌尿外科/男科,代谢性疾病中医药调控四川省重点实验室,四川 成都 610075
- 2. 太和县人民医院,安徽 太和 236600
- 折叠
摘要
近年来,男性不育发病率逐年上升,其中,睾丸生精上皮损伤影响睾丸的生精功能是男性不育的主要原因之一.铁死亡是一种新型细胞死亡方式.研究表明,铁死亡在睾丸细胞损伤中扮演了重要的角色.而部分中药可以通过调控睾丸生精上皮的铁死亡途径,进一步干预睾丸损伤的进展.因此,本文将重点探讨中药对睾丸细胞铁死亡途径的调控作用,并总结中药在干预睾丸生精上皮损伤方面的相关研究成果,为选择相关药物并将其应用于临床提供理论基础.
Abstract
The incidence of male infertility has been increasing year by year,and one of the major causes is testicular spermato-genic epithelial injury,which affects the spermatogenic function of the testis.Ferroptosis is a novel mode of cell death and plays an im-portant role in testicular cell injury.Some traditional Chinese medicines can intervene in the progression of testicular injury by regula-ting the ferroptosis pathway in testicular spermatogenic epithelia.This paper focuses on the effect of traditional Chinese drugs in regula-ting the ferroptosis pathway in testicular cells,and summarizes the advances in the studies of traditional Chinese medicines in the treat-ment of testicular spermatogenic epithelial injury,aiming to provide a theoretical basis for the selection of relevant medicines and their clinical application.
关键词
生精上皮/铁死亡/中药Key words
spermatogenic epithelium/ferroptosis/traditional Chinese medicine引用本文复制引用
基金项目
成都中医药大学附属医院院基金项目(y20200019)
出版年
2024
NETL
NSTL
万方数据