首页|中药调控铁死亡途径干预睾丸生精上皮损伤的研究进展

中药调控铁死亡途径干预睾丸生精上皮损伤的研究进展

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近年来,男性不育发病率逐年上升,其中,睾丸生精上皮损伤影响睾丸的生精功能是男性不育的主要原因之一.铁死亡是一种新型细胞死亡方式.研究表明,铁死亡在睾丸细胞损伤中扮演了重要的角色.而部分中药可以通过调控睾丸生精上皮的铁死亡途径,进一步干预睾丸损伤的进展.因此,本文将重点探讨中药对睾丸细胞铁死亡途径的调控作用,并总结中药在干预睾丸生精上皮损伤方面的相关研究成果,为选择相关药物并将其应用于临床提供理论基础.
Intervention of traditional Chinese medicine in spermatogenic epithelium injury by regulating the ferroptosis pathway:Advances in studies
The incidence of male infertility has been increasing year by year,and one of the major causes is testicular spermato-genic epithelial injury,which affects the spermatogenic function of the testis.Ferroptosis is a novel mode of cell death and plays an im-portant role in testicular cell injury.Some traditional Chinese medicines can intervene in the progression of testicular injury by regula-ting the ferroptosis pathway in testicular spermatogenic epithelia.This paper focuses on the effect of traditional Chinese drugs in regula-ting the ferroptosis pathway in testicular cells,and summarizes the advances in the studies of traditional Chinese medicines in the treat-ment of testicular spermatogenic epithelial injury,aiming to provide a theoretical basis for the selection of relevant medicines and their clinical application.

spermatogenic epitheliumferroptosistraditional Chinese medicine

魏锦涛、马紫阳、曹军、张培海

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成都中医药大学附属医院泌尿外科/男科,代谢性疾病中医药调控四川省重点实验室,四川 成都 610075

太和县人民医院,安徽 太和 236600

生精上皮 铁死亡 中药

成都中医药大学附属医院院基金项目

y20200019

2024

中华男科学杂志
南京军区南京总医院

中华男科学杂志

CSTPCD
影响因子:1.052
ISSN:1009-3591
年,卷(期):2024.30(5)