Expressions of PRMT5 and DKK3 proteins in prostate cancer tissue correlate to biochemical recurrence after radical prostatectomy
Objective:To investigate the relationship of the expression levels of protein arginine methyltransferase 5(PRMT5)and Dickkopf-related protein 3(DKK3)in the PCa tissue with biochemical recurrence(BR)of the malignancy after radical surgery.Methods:This study included 105 cases of PCa diagnosed in our hospital from January 2016 to December 2020 and,according to BR within 3 years after surgery,we divided them into a BR(n=22)and a non-BR group(n=83).We detected the expressions of PRMT5 and DKK3 in the prostate tissues of the patients by immunohistochemistry,analyzed the correlation of the expression levels of PRMT5 and DKK3 using the Spearman method,and conducted a multivariate analysis of postoperative BR of the malignancy using the Cox multivariate regression model.Results:The positive expression of PRMT5 was significantly higher while that of DKK3 remark-ably lower in the PCa than in the adjacent tissue(P＜0.05).Spearman correlation analysis showed a negative correlation between the expression levels of PRMT5 and DKK3 in the PCa tissue(r=-0.532,P＜0.05).The expressions of PRMT5 and DKK3 were sig-nificantly associated with tumor-node-metastasis(TNM)stages,positive surgical margins,peripheral nerve invasion,capsular inva-sion,seminal vesicle invasion and vascular invasion(P＜0.05).The percentage of TNM stages Ⅲ-Ⅳ,the positive expression of PRMT5 and the negative expression of DKK3 were remarkably higher in the BR than in the non-BR group(P＜0.05).PRMT5 was found to be an independent risk factor for while DKK3 a protective factor against postoperative BR of PCa in the patients(P＜0.05).Conclusion:PRMT5 is highly while DKK3 lowly expressed in PCa tissue,and their expressions are both closely related to the bio-chemical recurrence of PCa after radical surgery.
prostate cancerlaparoscopic radical prostatectomybiochemical recurrenceprotein arginine methyltransferase 5Dickkopf-related protein 3
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维普
