Salmonella infection is one of the common diseases in the poultry industry,posing a significant threat to the health of poultry and human public health.The aim of this study is to evaluate the preventive and therapeutic effects of the virulent bacteriophage KM104 on Salmonella infection in chicks with different serotypes of chickens.460 1-day-old healthy white feathered laying hens were selected for the experiment.Through in vitro experiments and in vivo safety tests,the lysis spectrum and antibacterial activity of KM104 against 68 different serotypes of Salmonella from chickens were explored.A bacteriophage prevention and control experiment against Salmonella infection from chicken sources was designed by measuring the lethal dose at 50%(LD50)of Salmonella and determining the optimal multiple of infection(MOI).The results showed that KM104 can significantly improve the survival rate of chicks,improve growth performance,alleviate clinical symptoms and pathological damage,reduce anal swab bacterial discharge and spleen bacterial load,and reduce organ damage.This study demonstrates that bacteriophage KM104,as a safe and effective biological agent,has potential application value in the prevention and control of Salmonella infection in chickens.
chickensalmonellachicken infectiongrowth performancepoultry health
国家科技期刊平台
NSTL
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