目的 评估重金属在甘草Glycyrrhizae Radix et Rhizoma中的健康风险,并测定其限量浓度.方法 计算甘草中6种重金属质量浓度及超标率,评估健康风险,蒙特卡洛模拟进行不确定性分析和敏感性分析,并测定其限量浓度.结果 Cu、Pb、As、Cd、Hg、Cr超标率分别为5.88％、26.00％、6.67％、3.33％、12.50％、35.00％,其限量浓度分别为24.60、2.31、0.185、0.615、0.43、922.51 mg/kg,宁夏产甘草的重金属安全性更高.结论 6种重金属均会造成较高的非致癌风险,并且As会引起致癌风险.Pb和As限量浓度应进一步降低以提高重金属安全性.
Evaluation of health risks and determination of limited concentrations of heavy metals in Glycyrrhizae Radix et Rhizoma
AIM To evaluate the health risks of heavy metals in Glycyrrhizae Radix et Rhizoma and to determine their limited concentrations.METHODS The concentrations and exceeding standard rates of six heavy metals in Glycyrrhizae Radix et Rhizoma were calculated.The health risks were evaluated,uncertainty analysis and sensitivity analysis were made by Monte Carlo simulation,then the limited concentrations were determined.RESULTS The exceeding standard rates of Cu,Pb,As,Cd,Hg and Cr were 5.88％,26.00％,6.67％,3.33％,12.50％ and 35.00％,whose limited concentrations were 24.60 mg/kg,2.31 mg/kg,0.185 mg/kg,0.615 mg/kg,0.43 mg/kg and 922.51 mg/kg,respectively.The safety of heavy metals in Glycyrrhizae Radix et Rhizoma cultivated in Ningxia was higher.CONCLUSION Six heavy metals can cause high noncarcinogenic risks,and As brings a carcinogenic risk.The limited concentrations of Pb and As should be further reduced for increasing the safety of heavy metals.
Glycyrrhizae Radix et Rhizomaheavy metalshealth riskslimited concentrationsMonte Carlo simulation
国家科技期刊平台
NSTL
万方数据
维普
