摘要
目的 考察肺宁排毒汤联合常规治疗对肺炎支原体大叶性肺炎患者的临床疗效.方法 90 例患者随机分为对照组和观察组,每组 45 例,对照组给予常规治疗,观察组在对照组基础上加用肺宁排毒汤,疗程 2 周.检测临床疗效、中医证候评分、炎症指标(WBC、N、CRP、ESR、PCT)、炎性细胞因子(TNF-α、IL-6、IL-8)、凝血指标(PLT、TT、PT、APTT、Fib、D-D)、肺部影像学积分、不良反应发生率变化.结果 观察组总有效率高于对照组(P<0.05).治疗后,2 组中医证候评分、炎症指标、炎性细胞因子、PLT、肺部影像学积分降低(P<0.05),以观察组更明显(P<0.05);观察组 TT、PT、APTT 延长(P<0.05),Fib、D-D 降低(P<0.05),并比对照组更明显(P<0.05).2 组不良反应发生率比较,差异无统计学意义(P>0.05).结论 肺宁排毒汤联合常规治疗可安全有效地缓解肺炎支原体大叶性肺炎患者临床症状,改善炎症反应和凝血功能.
Abstract
AIM To investigate the clinical effects of Feining Paidu Decoction combined with conventional treatment on patients with Mycoplasma pneumoniae lobar pneumonia.METHODS Ninety patients were randomly assigned into control group(45 cases)for 2-week intervention of conventional treatment,and observation group(45 cases)for 2-week intervention of both Feining Paidu Decoction and conventional treatment.The changes in clinical effects,TCM syndrome scores,inflammatory indices(WBC,N,CRP,ESR,PCT),inflammatory cytokines(TNF-α,IL-6,IL-8),coagulation indices(PLT,TT,PT,APTT,Fib,D-D),pulmonary imaging intergal and incidence of adverse reactions were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05).After the treatment,the two groups displayed decreased TCM syndrome scores,inflammatory indices,inflammatory cytokines,PLT,pulmonary imaging intergal(P<0.05),especially for the observation group(P<0.05);the observation group exhibited prolonged TT,PT,APTT(P<0.05),and decreased Fib,D-D(P<0.05),which were more obvious than those in the control group(P<0.05).No significant difference in incidence of adverse reactions was found between the two groups(P>0.05).CONCLUSION For the patients with Mycoplasma pneumoniae lobar pneumonia,Feining Paidu Decoction combined with conventional treatment can safely and effectively alleviate clinical symptoms,and improve inflammatory responses,coagulation functions.
基金项目
河南省中医药科学研究专项课题(20-21ZY2094)
河南省中医药科学研究专项课题(2023ZY2168)
维普
万方数据